摘要
目的评估丙型肝炎病毒感染与肝内胆管细胞癌（ICC）发病风险的关系。方法检索2000年1月至2015年5月Medline、Embase、Web of science、中国知网、维普、万方数据库评估丙型肝炎与肝内胆管细胞癌发病风险关系的文献，借助RevMan5．3软件应用随机效应模型对丙型肝炎病毒感染暴露风险比值比进行定量合成分析。结果分析共纳入14项病例对照研究和2项队列研究，异质性检验显示16项研究间存在明显异质性（I2=72％，P〈0．05），故采用随机效应模型。定量分析结果显示，肝内胆管细胞癌组与对照组丙型肝炎病毒感染暴露风险合并比值比为3．96（95％C1为2．63～5．95，P〈0．05）。16项纳入研究未见明显发表偏倚。结论丙型肝炎病毒感染可显著提高肝内胆管细胞癌的发病风险。
Objective A meta-analysis was conducted to evaluate the correlation between hepatitis C virus （HCV） infection and the incidence of intrahepatic cholangiocarcinoma （ICC）. Methods EMBASE, MEDLINE, Web of Science, CNKI, Weipu and Wanfang databases were retrieved to identify eligible studies which were published between January 2000 and May 2015. Pooled odds ratios （OR） with 95% confidence interval （95% CI） were calculated using RevMAN 5.3. Results 14 case-control studies and 2 cohort stu- dies were included in this study. As there was great heterogeneity among these 16 studies （Chi2 = 53.18, df = 15, 12 = 72% ,P 〈 0.05） , the random-effect model was employed. The combined risk estimates of all the studies showed a significant increase in ICC incidence with HCV infection （ OR = 3.96, 95% CI 2. 63 - 5.95, P 〈 0.05 ）. The Begg funnel plot showed no evidence of publication bias. Conclusion HCV infec- tion is related to an increased risk of ICC incidence.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2016年第1期33-36,共4页
Chinese Journal of Hepatobiliary Surgery
