摘要
目的探讨扩散张量纤维束示踪成像诊断无小脑病灶的多发性硬化患者共济失调的价值。方法对18例有共济失调症状的MS患者(MS组)和18名健康志愿者(对照组)进行头部MR扫描,利用纤维束示踪技术追踪穿过小脑双侧齿状核和双侧丘脑白质的纤维束,计算FA值、ADC值和纤维束条数,并进行统计学分析。结果与对照组比较,MS组右侧丘脑白质纤维束FA值减低、ADC值增加(P均<0.05);左侧丘脑、双侧齿状核FA值、ADC值差异均无统计学意义(P均>0.05);双侧丘脑、双侧齿状核的白质纤维束条数差异均无统计学意义(P均>0.05)。MS组双侧丘脑、双侧齿状核的FA值、ADC值、纤维束条数与临床扩展残疾状态量表评分、病程均无相关性(P均>0.05)。结论扩散张量纤维束示踪成像诊断无小脑病灶的多发性硬化患者共济失调有一定临床应用价值。
Objective To explore the value of diffusion tensor tractography in diagnosis of ataxia in multiple sclerosis （MS） patients without eerebellar lesions. Methods Totally 18 patients with MS （MS group） and 18 healthy volunteers （control group） underwent MR scan in the head. Tractography technique was adopted to tract the fibre bundle through bi- lateral dentate nucleus and bilateral thalamus white matter. The value of FA, AI）C and number of fiber bundle were calcu- lated, and statistical analysis was performed. Results Compared with control group, FA increased and ADC reduced of the right thalamus white matter fibre bundle in MS group （all P〈0.05）; FA and ADC of the left thalamus and bilateral den- tate nucleus had no statistically significant difference （all P〉0.05）; the fiber bundle number of bilateral dentate nucleus and bilateral thalamus white matter had also no statistically significant difference （all P〉0.05）. There was no correlation between FA, ADC and fiber bundle number of bilateral dentate nucleus and bilateral thalamus and expanded disability states scale score, course of disease （all P〉0.05）. Conclusion Diffusion tensor tractography has certain value in diagnosis of ataxia in MS patients without cerebellar lesions.
出处
《中国介入影像与治疗学》
CSCD
北大核心
2016年第2期94-97,共4页
Chinese Journal of Interventional Imaging and Therapy
基金
国家自然科学基金(81371523)
国家临床重点专科建设项目([2013]544)
重庆市卫生局资助项目(2011-1-031
2012-1-017)
