摘要
目地探讨纵隔钙化性纤维性肿瘤(CFT)的临床病理特征、免疫表型及诊断与鉴别诊断。方法对2例纵隔CFT的临床表现、病理学形态、免疫组化进行观察,并复习文献。结果 2例均为女性,年龄分别为24岁和47岁,均为检查时偶然发现纵隔占位。肿瘤最大直径分别为4 cm和4.5 cm。镜下肿瘤边界清楚,由大量致密的胶原纤维组成,细胞稀少,肿瘤广泛分布砂砾钙化小体,胶原纤维间夹杂少量形态温和的梭形细胞。少量散在的淋巴细胞、浆细胞和嗜酸性粒细胞浸润,淋巴细胞灶性聚集,次级淋巴滤泡形成。免疫组化示2例瘤细胞vimentin(+),CD34局灶(+);1例浆细胞Ig G4散在(+)。结论纵隔CFT是一种罕见的良性间叶性肿瘤,病理诊断依赖特征性的组织学表现。还需与孤立性纤维性肿瘤、炎症性肌纤维母细胞瘤、韧带样型纤维瘤病、硬化性胸腺瘤和淀粉样瘤等相鉴别。
Objective To study the clinicopathologic features, diagnosis, differential diagnosis and treatment of calcifying fibrous tumor （CFT）. Methods The clinical manifestations, histopathologic characteristics and immunophenotypes were analyzed in 2 cases of CFI＇, and related literatures were reviewed. Results The CFT came from 2 female patients （24 and 47 years of age at diagnosis）. The 2 cases of mediastinal mass were accidentally discovered on their examinations. The tumors measured 40, and 45 mm in the largest diameter, respectively. Histologically, the tumors were well-circumscribed but unencapsulated masses showing hypocellular, densely hyalinized collagenous fibrotic tissues interspersed with bland spindle cells and extensive psammomatous calcifications. Admixed within the tumor was a variably prominent lymphocytes, plasma cells, and eosnophils. The inflammatory cells were scattered in the collagenous background and were compactly arranged, formed follicles with germinal centers. Immunostaining showed vimentin positivity, CD34 focal positive in the 2 cases. One case was scattered positive for IgG4. Conclusion CFF of mediastinum is a rare, benign mesenchymal tumor. The diagnosis is based on characteristic histopathologic manifestations. CFT should be distinguished from other tumors or tumor-like lesions, such as solitary fibrous tumor, inflammatory myofibroblastic tumour, desmoid type fibromatosis, sclerosing thymoma and amyloid tumor.
出处
《诊断病理学杂志》
CSCD
2016年第1期5-9,共5页
Chinese Journal of Diagnostic Pathology
关键词
钙化性纤维性肿瘤
纵隔
临床病理
鉴别诊断
Calcifying fibrous tumor
Mediastinum
Clinicopathologic features
Differential diagnosis
