摘要
目的:探讨克罗米芬(CC)与GnRH拮抗剂(GnRH-A)在控制性超促排卵(COH)中对黄体生成素(LH)峰抑制效果的比较。方法:对应用CC后置方案和拮抗剂方案的181个周期的资料进行回顾性分析。其中应用CC抑制LH峰方案65例(CC组),应用GnRH-A(思则凯组)抑制LH峰方案116例。比较2种药物对LH峰的抑制作用、Gn用量、获卵数、可移植胚胎数、优质胚胎数、受精率等。结果:hCG注射日LH值与加用CC或思则凯日LH值的差值[LH(d-)]具有统计学差异(1.30±5.12 IU/L vs-1.37±7.15 IU/L,P=0.004);Gn用量、获卵数、可移植胚胎数、优质胚胎数、受精率等CC组和思则凯组比较差异无统计学意义(P>0.05)。结论:CC与思则凯对早发LH峰均有一定抑制效果,但较CC相比其抑制早发LH峰效果可能更明显。
Objective： To compare the availability of clomiphene citrate （CC） with CmRH-A （Cetrotide） in controlled ovarian hyperstimulation （COH） to suppress premature LH surge. Methods： A total of 181 cycles from infertile patients who underwent COH were retrospectively analyzed. The patients were divided into CC group （administered with CC to suppress LH surge, n=65） and CmRH-A group （administered with Cetrotide to suppress LH surge, n=116）. The difference of clinical outcome was compared and analyzed between the two groups. Results： The serum LH value on hCG injection day in CC group was statistically lower than that in GnRH-A group, and the difference was statistically significant （P〈0.05）. No statistically significant difference was found between the two groups in oocyte number and transferable embryo number （P〉005）. Conclusion： Both CC and CmRH-A are effective to suppress premature LH surge, but the effect might be better in CC group.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2016年第1期38-41,共4页
Reproduction and Contraception
基金
新疆医科大学第一附属医院青年专项科研基金项目
项目号:2012QN16
