摘要
目的连续监测并分析医院实行抗菌药物干预政策后临床分离病原菌耐药性变化,评估抗菌药物干预与病原菌耐药性相关性。方法选取近3年实行抗菌药物干预的第三、四代头孢菌素,连续3年动态监测肠杆菌科病原菌对其耐药性的变化,设干预组和对照组。结果干预前后产ESBLs菌株检出率有显著性下降(P<0.05);病原菌对干预使用的第三、四代头孢菌素耐药性降低,干预前后差异有统计学意义(P<0.05);而病原菌对对照1组抗菌药物哌拉西林/他唑巴坦和阿莫西林/棒酸耐药性无显著增加,对对照2组抗菌药物耐药性影响不大。结论长期合理对抗菌药物进行综合干预有益于延缓病原菌耐药性。
Objective To continuously monitor and analyze the drug resistance change of clinically isolated pathogenic bacteria after implementing the hospital antibiotic interventional policy and to evaluate the correlation between the antibiotic intervention and drug resistance of pathogenic bacteria.Methods Third-generation and fourth generation cephalosporins implementing the antibiotic intervention for recent 3years were selected and the change of resistance of Enterobacteriaceae pathogenic bacteria to them were continuously monitored for 3successive years.The intervention group and the control group were set up.Results The detection rate of ESBLs producing strains were significantly decreased after intervention（P〈0.05）;and the resistance rates of pathogens to used third-generation and fourth generation cephalosporins were reduced with statistically significant difference between before and after intervention（P〈0.05）;the resistance of pathogenic bacteria to piperacillin/tazobactam and amoxicillin/clavulanic acid in the control group 1had no significant increase,the resistance to antibiotics in the control group 2had little influence.Conclusion The long-term and rational comprehensive intervention to antibiotics is beneficial to delay the drug resistance of pathogenic bacteria.
出处
《国际检验医学杂志》
CAS
2016年第1期31-32,共2页
International Journal of Laboratory Medicine
关键词
细菌耐药性
抗菌药物干预
动态监测
bacterial drug resistance
antibiotic intervention
dynamic surveillance
