摘要
目的了解肇庆市全人群麻疹、风疹、流行性腮腺炎抗体水平,为控制相应疾病、改善免疫策略提供科学依据。方法按分层随机原则抽取肇庆市三个县区2012年全人群血清标本共319份,用酶联免疫吸附试验定量检测麻疹、风疹、流行性腮腺炎Ig G抗体水平。结果肇庆市2012年全人群麻疹抗体阳性率为88.40%、抗体几何平均浓度(Geometric Mean Concentration,GMC)为1167.95m IU/ml;风疹抗体阳性率为78.06%、GMC为146.10IU/ml;流行性腮腺炎抗体阳性率为74.92%,GMC为447.96U/ml。人群麻疹、风疹抗体阳性率在不同县区、年龄段、性别、城乡之间没有统计学差异;流行性腮腺炎抗体阳性率在城乡之间没有统计学差异,在不同县区、不同年龄段、性别之间有统计学差异(X^2=9.760,P<0.05;X^2=36.509,P<0.05;X^2=5.575,P<0.05);低龄儿童麻疹、风疹、流行性腮腺炎抗体阳性率和GMC偏低,20~29岁年龄段人群麻疹、风疹抗体阳性率和GMC不高。结论肇庆市全人群对麻疹、风疹、流行性腮腺炎疾病已建立一定的免疫屏障,但应加强对低龄儿童的预防接种工作,及时为8~11月龄儿童接种麻疹风疹联合减毒活疫苗(MR)、1.5岁以上儿童接种麻腮风联合减毒活疫苗(MMR);建议为20~29岁育龄期妇女接种MR或MMR,进一步提高全人群防病水平。
Objective To analyze the antibody levels of measles,rubella and mumps among whole population in Zhaoqing city to provide evidences for the relevant disease control and the improvement of vaccination strategy. Methods Three counties were selected by stratified random sampling and total 319 serum samples were obtained. Enzyme-linked immunosorbent assay（ ELISA） was used to test the measles,rubella and mumps antibody. Results The measles antibody positive rate among population in Zhaoqing,2012 was 88. 40% with Geometric Mean Concentration（ GMC） 1167. 95 m IU / ml. The positive rate of rubella antibody was 78. 06% with GMC 146. 10 IU / ml. The positive rate of mumps was 74. 92%with GMC 447. 96 U / ml. No statistically significant differences were found in the positive rates of measles and rubella antibody between counties,ages,genders,or between urban and rural areas,while the positive rates of mumps antibody had no statistically significant differences between urban and rural areas,but between counties,ages or genders（ x^2= 9. 760,P 0. 05; x^2= 40. 229,P 0. 05; x^2= 5. 575,P 0. 05）. Measles,rubella and mumps antibody positive rates and GMC among young children were low.The positive rates and GMC of measles and rubella antibody among 20 ~ 29 years of age group were not high. Conclusion A certain immune barrier against measles,rubella and mumps among the whole population in Zhaoqing has established. But the vaccination for younger children should be strengthened,andchildren aged 8-11 months and more than 1. 5years of age should be vaccinated with measlesrubella vaccine（ MR） and measles-rubellamumps vaccine（ MMR）,respectively. It is recommended that women aged 20 ~ 29 years should be vaccinated with MR or MMR to further improvethe antibody level among the whole population for disease prevention.
出处
《中国疫苗和免疫》
北大核心
2015年第5期519-523,542,共6页
Chinese Journal of Vaccines and Immunization
