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联合检测血清降钙素原、高敏C反应蛋白和全血白细胞在鉴别小儿细菌性和病毒性脑膜炎病中的重大意义 被引量:4

The Great Significance of Combined Detection of Serum Procalcitonin(PCT), High-sensitivity c-reactive Protein(hs- CRP) and White Blood Cells in Whole Blood in the Identification of Children with Bacterial Meningitis and Viral Meningitis
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摘要 目的评价联合检测血清降钙素原(PCT)、高敏C反应蛋白(hs-CRP)及全血白细胞(WBC)在鉴别小儿细菌性和病毒性脑膜炎的重大意义。方法分别检测42例细菌性脑膜炎患儿、56例病毒性脑膜炎患儿及40例健康对照儿童的血清PCT、hs-CRP及全血WBC。结果 1细菌组的血清PCT、hs-CRP和WBC水平显著高于正常对照组水平,有统计学意义(P<0.05);病毒组血清PCT、hs-CRP和全血WRC水平与健康对照组水平差异无统计学意义(P>0.05)。2三项指标联合检测鉴别细菌性和病毒性脑膜炎病在准确度,灵敏度和特异性上明显高于单独检测任一项指标,差异有统计学意义(P<0.05)。结论联合检测血清降钙素原、高敏C反应蛋白和全血白细胞有助于鉴别小儿细菌性和病毒性脑膜炎。 Objeetive To evaluate the significance of serum procalcitonin(PCT), high-sensitivity c-reactive protein (hs-CRP) and white blood cells in whole blood in identifying children with bacterial meningitis and viral meningitis. Methods To detecte PCT, hs-CRP and whole blood WBC taken from 42 children with bacterial meningitis, 56 children with viral meningitis and 40 healthy controls children. Results OThe level of PCT, hs-CRP and whole blood WBC in children with bacterial meningitis were significantly higher than that in control group. There was significant difference between the two groups(P〈0.05). And no difference between the viral meningitis group and control group(P〉0.05). ~The combined detection of the three indicators in the identification of bacterial meningitis and viral encephalitis in accuracy, sensitivity and specificity was significantly higher than on an individual detection. There was significant difference between the two ways(P〈0.05). Conclusion Combined detection of PCT, hs-CRP and white blood cells in whole blood can help identify children with bacterial and viral meningitis.
作者 张保珍
出处 《中国医药指南》 2016年第2期21-22,共2页 Guide of China Medicine
关键词 血清降钙素原(PCT) 高敏C反应蛋白(hs-CRP) 细菌性脑膜炎 病毒性脑膜炎 鉴别诊断 Serum procalcitonin(PCT) High-sensitivity c-reactive protein (hs-CRP) Bacterial meningitis Viral meningitis Differential diagnosis
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