摘要
目的:观察脉安宁合剂与盐酸普罗帕酮片治疗特发性期前收缩(IPC)患者的疗效及安全性。方法:88例IPC患者,按随机数字表法分为对照组A(30例)、对照组B(30例)和治疗组(28例);对照组A患者给予脉安宁合剂100 ml,bid;对照组B患者给予盐酸普罗帕酮片150 mg,tid;治疗组患者给予同等剂量脉安宁合剂联合盐酸普罗帕酮片治疗,3组患者均治疗4周,观察3组患者治疗后期前收缩疗效、心电图疗效、中医症候疗效、Holter期前收缩总数及不良反应情况。结果:治疗组患者总有效率显著高于对照组A与对照组B(90.00%vs.83.33%vs.82.14%),差异有统计学意义(P<0.05);治疗组患者中医证候总有效率优于对照组A与对照组B(90.00%vs.83.33%vs.75.00%),差异有统计学意义(P<0.05);治疗后,3组患者Holter期前收缩总数显著降低,且治疗组显著低于对照组A与对照组B[(1 936.47±1 913.68)次/d vs.(2 411.65±4 140.29)次/d vs.(2 834.40±4 599.06)次/d],差异有统计学意义(P<0.05);治疗后,3组患者心电图疗效比较,差异无统计学意义(P>0.05)。3组患者治疗期间均未见明显不良反应发生。结论:脉安宁合剂联合盐酸普罗帕酮片能显著降低患者的期前收缩总数,明显改善中医证候,提高临床疗效,且安全性好。
OBJECTIVE：To observe Mai＇anning mixture combined with Propatenonel in the treatment of idiopathic premature contraction（IPC）.METHODS：88 IPC patients were randomly divided into control group A,control group B and treatment group.Control group A was given Mai＇anning mixture 100 ml,bid;control group B was given propatenone 150 ml,tid.Treatment group received equivalent volume of Mai＇anning mixture combined with cardiac rhythm therapy.3 groups received 4 weeks of treatment.Premature contraction eficacy,electro cardiogram eficacy,TCM syndromes eficacy,total number of hdter premature contraltion and ADR were observed in 3 groups after treatment.RESULTS：Total effective rate of treatment groups was significantly higher than control group A and B（90.00% vs.83.33% vs.82.14%）,with statistical significance（P〈0.05）.Total effective rate of TCM syndrome in treatment group was better than control group A and control group B（90.00% vs.83.33% vs.75.00%）,with statistical significance（P〈0.05）.After treatment,total Holter premature contraction count of 3 groups decreased significantly,and that of treatment group was lower than that of control group A and control group B [（1 936.47 ± 1 913.68）times/d vs.（2 411.65 ± 4140.29）times/d vs.（2 834.40±4 599.06）times/d],with statistical significance（P〈0.05）.After treatment,there was no statistical significance in electrocardiogram among 3 groups（P〉0.05）.No obvious ADR was found in 3 groups during treatment.CONCLUSIONS：Mai＇anning mixture combined with Propatenonel can significantly decrease total premature contraction count,improve TCM syndrome and clinical efficacy with good safety.
出处
《中国药房》
CAS
北大核心
2016年第2期255-257,共3页
China Pharmacy
