摘要
目的探讨急性上消化道出血(UGIH)患者外周血炎症指标变化及临床意义。方法选取2014年1月至2015年4月收治的72例UGIH患者为研究对象(UGIH组),收集其外周血样标本,检测C反应蛋白(CRP)、白细胞介素(IL)-6和IL-10水平,同时选取年龄、性别匹配的消化性溃疡患者68例(溃疡组)和健康体检者50例(健康组)为对照。结果 UGIH组的CRP、IL-6和IL-10水平为(8.94±2.53)mg/L、(7.24±2.67)pg/L和(1.43±0.89)pg/L,其CRP水平与IL-6呈正相关(r=0.527),IL-10水平与CRP、IL-6与呈负相关(r=-0.367、-0.442)。UGIH组CRP、IL-6水平高于对照组和溃疡组,而IL-10水平低于对照组和溃疡组(P<0.05),且治疗后的以上指标获改善(P<0.05)。结论 UGIH患者外周血炎症指标出现异常,可用于辅助UGIH诊断并反映疗效。
Objective To explore the changes and significance of peripheral blood inflammatory markers in patients with acute upper gastrointestinal hemorrhage（ UGIH）. Methods From January 2014 to April 2015,72 patients with UGIH were selected as the research object（ UGIH group）,and their blood samples were collected. We analyzed the levels of C- reactive protein（ CRP）,interleukin（ IL）- 6 and IL- 10. 50 patients with peptic ulcer（ ulcer group） and 68 cases healthy physical examination clients（ healthy group） were selected as control. Results The levels of CRP,IL- 6 and IL- 10 were（ 8. 94 ± 2. 53） mg / L,（ 7. 24 ± 2. 67） pg / L and（ 1. 43 ± 0. 89） pg / L in UGIH group. The level of CRP was positively correlated with IL- 6（ r = 0. 527）,and IL- 10 level was negatively correlated with CRP（ r =- 0. 367）and IL- 6（ r =- 0. 442）. Compared with other two groups,there were higher CRP and IL- 6 but lower IL- 10 in UGIH group（ P〈0. 05）,which were improved after treatment. Conclusion Peripheral blood inflammatory markers were abnormal in patients with UGIH,which may be used in the diagnosis and treatment of UGIH.
出处
《医药论坛杂志》
2015年第12期20-21,共2页
Journal of Medical Forum
关键词
急性上消化道出血
外周血
炎症指标变化
Acute upper gastrointestinal hemorrhage
Peripheral blood
Inflammatory index changes
