摘要
目的:对中西医结合治疗下肢深静脉血栓形成的有效性做出比较客观的评估。方法:计算机检索中国生物医学文献数据库、万方数据资源系统、中国学术期刊全文数据库、中国知网、中文科技期刊数据库、Pub Med、EMBase,纳入符合标准的随机对照试验(RCT),并采用Rev Man 5.2软件进行Meta分析。结果:共9篇文献760例患者符合纳入标准,未发现双盲试验。根据意向治疗分析显示与常规西医西药治疗相比,结合中医中药治疗下肢深静脉血栓形成对总有效率的影响差异有统计学意义[P<0.01,优势比为7.68(3.48,16.97)],对治愈率的影响差异也有统计学意义[P<0.01,优势比为2.75(1.97,3.83)]。漏斗图显示基本对称,提示纳入文献的发表性偏倚控制尚可。结论:以本项Meta分析为基础,中西医结合治疗下肢深静脉血栓形成较单纯西医治疗有益,但受纳入文献质量限制,以上结论尚需要高质量的临床试验进一步证实。
Objective：To make an impersonal evaluation on the effect of integrated traditional Chinese and Western medicine for deep venous thrombosis（DVT）. Methods：Retrieved from CBD,Wanfang database,CSJD,NKI,CNKI,Pub Med,EMBase and related journals,literatures meeting inclusion criteria were collected. Meta-analysis was performed by Rev Man 5.2 software. Results：9 RCTs,including 760 patients,met the inclusion criteria.All of the trials were not adequate in methodological quality. None of them was double-blinded trial. Compared with basic Western medicine only,the result of analysis（intention-to-treat,ITT）showed that integrated traditional Chinese and Western medicine could raise both total clinical effective rate[P〈0.01,OR 7.68（3.48,16.97）]and cure rate[P〈0.01,OR 2.75（1.97,3.83）].There was not a significant funnel plot asymmetry,which means no significant publication bias has been found. Conclusion：The present meta-analysis suggests that integrated traditional Chinese and Western medicine is beneficial over basic Western medicine for DVT.But limited by the quality of included studies,the above conclusions still need high-quality clinical trials for further confirmation.
出处
《辽宁中医药大学学报》
CAS
2016年第1期178-181,共4页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
中西医结合
下肢深静脉血栓
药物治疗
随机对照试验
META分析
integrated traditional Chinese and Western medicine
deep venous thrombosis
medicine treatment
randomized controlled trials
meta-analysis
