摘要
目的通过检测健康孕妇在妊娠中、晚期时的血脂水平，建立妊娠中、晚期孕妇的血脂水平正常参考值区间。方法收集2014年1月-2015年2月复旦大学附属妇产科医院产科分娩的3200例健康孕妇为健康妊娠组，同时收集3200例健康育龄期妇女作为健康对照组。采用日立7180型全自动生化分析仪检测两组妇女血清中甘油三酯（TG）、总胆固醇（TCH）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A（APO．A）和载脂蛋白B（APO—B）水平；其中健康妊娠组孕妇分别在孕14—20周、24—28周、37—40周进行检测。将检测结果按全国临床和实验室标准化研究院制定的C28．A3标准，计算并确定妊娠中、晚期孕妇血脂水平正常参考值区间，即百分数范围为2．5％-97．5％时的血脂水平。结果（1）血脂水平：健康对照组妇女血清TG、TCH、HDL、LDL、APO．A和APO．B水平的中位数分别为0．8、4．2、1．0、2,7mmol／L和1．1、0．8g／L，健康妊娠组孕妇不同孕周TG、TCH、HDL、LDL、APO．A和APO．B水平均高于健康对照组，两组比较，差异均有统计学意义（P〈0．05）。（2）健康妊娠组孕妇血脂水平在孕14—20周、24～28周、37～40周分别与健康对照组比较：TG水平升高1．9、3．8和4．4倍，TCH水平升高1．1、1．5和1．5倍，HDL水平升高1．2、1．6和1．5倍，LDL水平升高1．1、1．4和1．4倍，APO—A水平升高1．3、1．4和1．5倍，APO—B水平升高1．1、1．5和1．5倍。其中TG水平的升高幅度最大，并随孕周进展逐渐升高（P〈0．01）。（3）健康妊娠组孕妇血清LDL／HDL比值的中位数在孕14～20周为2．7、孕24—28周为2．5、孕37～40周为2．6。与健康对照组的2．8比较，健康妊娠组妊娠中、晚期孕妇血清LDL／HDL比值有不同程度的降低，两组比较，差异均有统计学意义（P〈0．05）。（4）健康妊娠组孕妇孕14～20�
Objective To explore the serum lipids levels in healthy pregnant women, and to establish the reference intervals of serum lipids in middle and late pregnancy. Methods Triglyceride （TG）, total cholesterol （TCH）, high density lipoprotein （HDL）, low density lipoprotein （LDL）, apo-lipoprotein-A （APO-A） and apo-lipoprotein-B （APO-B） were measured in 3 200 pregnant women and 3 200 healthy women of childbearing age（the control group） from January 2014 to Febuary 2015 in Obstetrics and Gynecology Hospital of Fudan University. In the healthy pregnant women, serum lipids were measured at 14-20, 24- 28 and 37-40 gestational weeks, respectively. All the parameters were detected by Hitachi 7180 automatic biochemical analyzer. The test results were calculated and determined by the C28-A3 standard of the National Clinical and Laboratory Standards Institute. And the normal reference intervals of serum lipids in middle and late pregnancy were defined as 2.5%-97.5%. Results （1） The levels of TG, TCH, HDL, LDL, APO-A and APO-B in the control group were 0.8, 4.2, 1.0, 2.7 mmol/L and 1.1, 0.8 g/L, respectively. The levels of TG, TCH, HDL, LDL, APO-A and APO-B in middle and late pregnancy were significantly higher than those in the control group （P〈0.05）. （2） The serum lipids levels at 14-20, 24-28 and 37-40 gestational weeks in healthy pregnant women were compared with the control group as following. The TG levels were 1.9, 3.8 and 4.4 folds of the control group; the TCH levels were 1.1, 1.5 and 1.5 folds of the control group; the HDL levels were 1.2, 1.6 and 1.5 folds of the control group; the LDL levels were 1.1, 1.4 and 1.4 folds of the control group; the APO-A levels were 1.3, 1.4 and 1.5 folds of the control group; and the APO-B levels were 1.1, 1.5 and 1.5 fold of the control group respectively. The TG level was the most increased, and it increased gradually with gestational age （P〈0.01）. （3） The median of LDL to HDL cholesterol ratio in the healthy pregnancy group at 14-20, 2
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2015年第12期926-930,共5页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠
脂类
参考值
Pregnancy
Lipids
Reference values
