摘要
目的调查任丘地区人乳头瘤病毒(HPV)感染、基因型和年龄特征的流行病学情况。方法对2010-2014年某院妇产科就诊的6 230名妇女进行下生殖道HPV感染分型检测,采用核酸分子快速导流杂交基因芯片技术(Hybri Max)检测21种亚型,其中高危型(high-risk types,HR-HPV)15种、低危型(low-risk typeset,LR-HPV)6种。结果在6 230份标本中,阳性标本1 664份(26.71%),单纯感染1 213例(19.47%)、多型感染451例(7.23%)。感染率占前5位的亚型分别是:HPV16型335份(5.38%)、52型334份(5.36%)、58型243份(3.90%)、6型164份(2.63%)、53型152份(2.44%)。高危型HPV16、HPV52和HPV58及低危型HPV8304和HPV11检出率逐年下降;≤20岁年龄组HPV检出率最高,为52.04%。结论任丘地区HPV阳性检出率为26.70%,主要为HPV16、HPV52、HPV58、HPV6和HPV53,人群感染高峰为≤20岁年龄组。HPV检测可有效防治宫颈癌的发生。
Objective To investigate the epidemiology of HPV infection,genotype and age characteristics in Renqiu area. Methods In January 2011 to December 2014,623 cases of our hospital obstetrics and gynecology clinic of women of reproductive tract HPV infection was detected and the nucleic acid molecules fast flow-through hybridization and gene chip technology（ COMS） detection of 21 kinds of sub-type,which those high-risk types with high-risk HPV） 15,lr-hpv low-risk type（ low-risk typeset LR-HPV 6 kinds of methods. Results in 6230 cases,1664（ 26. 70%） were positive,1213 cases（ 19. 47%） were infected,and 451 cases（ 7. 23%）. The infection rate was 52 in the first 5 sub-types： HPV16 type 335（ 5. 38%）,type 334（ 5. 36%）,type 243（ 3. 90%）,type 164（ 2. 63%）,53（ 6）,152（ 2. 44%）. The positive rates of HPV16,HPV52,HPV8304,HPV11 and HPV58 were decreased year by year,and the detection rate of HPV was 913（ 34. 2%） in all patients. Conclusions The positive detection rate of HPV in this region was 26. 70%,which was mainly HPV16,HPV58,HPV52,HPV6 and HPV53,and the peak of population infection was from 31 to 40.
出处
《医学动物防制》
2015年第12期1337-1339,共3页
Journal of Medical Pest Control
