摘要
目的借助星点设计效应面法优化耐冻融茴三硫口服纳米乳剂的最优处方。方法采用超声波细胞粉碎仪制备茴三硫口服纳米乳剂,依据星点设计效应面法,以平均粒径、变异系数及冻融稳定性常数为评价指标,考察处方中聚氧乙烯40氢化蓖麻油、大豆卵磷脂及中链甘油三酸酯的用量对制剂的影响,预测最优处方。结果最优处方制得的茴三硫口服纳米乳剂的平均粒径为(163.7±0.3)nm,变异系数为0.290±0.035,冻融稳定性常数为1.84±0.03,与预测值相比偏差较小。结论星点设计效应面法所建立的模型能较好地用于茴三硫口服纳米乳剂的处方优化。
Objective To optimize the preparation of anethol trithione oral nanoemulsion using the central composite design response surface methodolody（ RSM-CDD）. Methods The anethol trithione oral nanoemulsion was prepared by ultrasonic cell grinder. In the RSM-CCD,mean diameter,coefficient of variation and constant of freeze-thawstability were selected as response variables,RH40,SPC,M CT were employed as independent variables. The optimal formulation was predicted by the RSM-CCD. Results The mean diameter,coefficient of variation and freeze-thawstability of the optimal preparation respectively were（ 163. 7 ±0. 3） nm,（ 0. 290 ± 0. 035） and（ 1. 84 ± 0. 03）. The deviations between measured values and predicted values were not considerable. Conclusion The model established by the RSM-CCD method can be rational for optimization of the preparation of anethol trithione oral nanoemulsion.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2015年第12期918-924,共7页
Journal of Shenyang Pharmaceutical University
关键词
茴三硫
口服纳米乳剂
星点设计效应面法
冻融稳定性常数
anethol trithione
oral nanoemulsion
central composite design-response surface methodology
freeze-thaw stability constant
