摘要
氰戊菊酯作为一种Ⅱ型拟除虫菊酯类农药,其毒性作用小,适用范围广。人群和动物实验研究发现,氰戊菊酯可损伤精子并表现出一定的遗传毒性。动物实验还出现间质细胞的损伤、睾丸的组织标志酶活性下降,氰戊菊酯的雌性化作用等。其毒性作用大小与暴露时间、剂量相关。对于雌性生殖系统能够显著抑制大鼠窦前卵泡生长发育,抑制大鼠窦前卵泡类固醇激素的合成,干扰卵巢细胞的钙稳态,抑制促性腺激素刺激下卵巢颗粒细胞类固醇合成。本文主要综述了目前国内外有关氰戊菊酯对生殖系统毒性的研究进展,旨在为类似研究提供依据。
Fenvalerate is a type Ⅱ pyrethroid pesticide with low toxicity and wide application range. Human and animal experiments have shown that it has some sperms damage effect and a certain genetic toxicity,besides,animal experiments also found it could induce interstitial cell damage,activity decrease of testicular markers enzyme,and feminization effect,etc.,the toxicity is related to exposure time and exposure dose. In female rats,fenvalerate can significantly inhibit the growth and development of preantral follicle and synthesis of follicular steroid hormone,interfer calcium homeostasis of ovarian cells,and suppress steroid synthesis of inferior ovarian granulosa cells by gonadotropin stimulation. This paper mainly reviewed the progress of researches on reproductive toxicity of fenvalerate,thereby provides some basis for future study.
出处
《中国工业医学杂志》
CAS
2015年第6期435-438,共4页
Chinese Journal of Industrial Medicine
关键词
氰戊菊酯
生殖系统
生殖毒性
农药
fenvalerate
reproductive system
reproductive toxicity
pesticides
