摘要
目的探讨MMP-9、TIMP-1在乳腺癌患者放疗后的表达及其临床意义。方法收集40例乳腺癌患者放疗前后的血清,以ELISA法检测MMP-9、TIMP-1表达,并分析其与年龄、TNM分期、肿瘤长度、淋巴结转移情况的相关性。结果 MMP-9、TIMP-1表达在乳腺癌患者的年龄、TNM分期、肿瘤长度及淋巴结转移之间有统计学差异（P〈0.05）;与放疗前比较,MMP-9表达上升,TIMP-1下降（P〈0.05）,MMP-9/TIMP-1比值增加（P〈0.05）。Kaplan-Meier分析发现,中位生存期为36.00（95%CI=35.13～36.88）个月。放疗前、后MMP-9/TIMP-1比值高度相关,R=0.907。结论乳腺癌患者放疗后MMP-9、TIMP-1表达改变,与患者预后密切相关,可作为乳腺癌放疗后预后的重要指标。
Objective To investigate the clinical significance of MMP-9 and TIMP- 1 expression after radiotherapy in breast cancer.Methods Serum of 40 breast cancer patients were collected before and after radiotherapy.The expression of MMP-9 and TIMP-1 were measured by ELISA,and analyzed the relationship between age,TNM stage,tumor length,and lymphatic metastasis.Results There was statistics difference in age,TNM stage,tumor length and lymphatic metastasis in patients with breast cancer by means of the expression of MMP- 9 and TIMP- 1（ P〈0.05）.The expression of MMP-9 was increasing compared with pre-radiotherapy,as to MMP-9 /TIMP-1 ratio,the TIMP-1 was decreased（ P〈0.05）.The median survival time was 36.00（ 95% CI = 35.13 ～ 36.88） months by Kaplan-Meier. There was high correlation of MMP- 9 / TIMP- 1 ratio before and after radiotherapy with equal to0.907 of R.Conclusion There is changed expression of MMP- 9 and TIMP- 1 and has closely correlated with the prognosis of patients,and can be used as an important index of prognosis in breast cancer after radiotherapy.
出处
《青海医学院学报》
CAS
2015年第4期264-267,共4页
Journal of Qinghai Medical College
基金
青海省卫生计划生育委员会项目
