摘要
分析心型脂肪酸结合蛋白(HFABP)及心肌钙蛋白(c Tn I)对慢性肾脏病(CKD)患者缺血性心肌损害的评估应用价值.选取非透析的慢性肾脏病患者,进行腺苷负荷心肌灌注显像检查,同时检测HFABP、c Tn I,并与腺苷负荷试验结果进行对比分析,明确HFABP及c Tn I对缺血性心肌损害的评估价值.结果发现HFABP与e GFR负相关,与CREA、BUN正相关,c Tn I与IVST、LVPWT正相关,有31.1%的患者腺苷负荷心肌灌注显像试验阳性,HFABP在腺苷负荷试验阳性组及阴性组患者间的差异无统计学意义,c Tn I的差异有统计学意义,腺苷负荷试验阳性结果与HFABP不相关(r=0.041,P=0.654),与c Tn I正相关(r=0.649,P<0.01).结果表明:HFABP受肾小球滤过率的影响较大,不是反映慢性肾脏病患者缺血性心脏损害的理想指标,c Tn I不受年龄和肾功能的直接影响,是腺苷负荷心肌灌注缺损的独立危险因素,腺苷负荷核素心肌灌注显像是评估CKD患者冠状动脉疾病的有效手段.
The ischemic myocardial damage evaluation value of heart type fatty acid binding protein and cardiac troponin I in CKD patients is explored in this paper. Adenosine stress myocardial perfusion imaging is performed to all patients whose levels of HFABP and c Tn I are also measured and compared with adenosine stress test results to assess the ischemic myocardial damage evaluation value of HFABP and c Tn I. It is observed that HFABP is negatively correlated with e GFR,and positively correlated to CREA and BUN,and that c Tn I is positive correlated with IVST and LVPWT. 31. 1% patients have positive results in adenosine stress test,the positive results being positively correlated with c Tn I（ r = 0. 649,P 0. 01）,and having no correlation with HFABP（ r = 0. 041,P = 0. 654）. The results show that HFABP is strongly influenced by glomerular filtration rate,and thus not an ideal index of ischemic heart damage in CKD patients. CTn I is not directly affected by age or renal function,which is an independent risk factor for the defect of adenosine stress myocardial perfusion. Adenosine stress myocardial perfusion imaging is proved to be an effective evaluation method for coronary artery disease in CKD patients.
出处
《昆明理工大学学报（自然科学版）》
CAS
2015年第6期89-95,共7页
Journal of Kunming University of Science and Technology(Natural Science)
基金
云南省应用基础研究计划项目(2011FZ281)
关键词
慢性肾脏病
心型脂肪酸结合蛋白
腺苷负荷心肌灌注显像
心肌钙蛋白Ⅰ
chronic kidney disease
heart type fatty acid binding protein
adenosine stress myocardial perfusion imaging
cardiac troponin I
