摘要
目的探讨鄂州市两所医院泌尿外科住院患者发生医院感染病原菌分布及耐药性,为预防与控制医院感染提供科学的参考依据。方法对2011年1月-2014年6月224例泌尿外科医院感染患者临床资料进行分析,研究感染部位及病原菌分布,数据采用WHONET 5.6软件进行统计分析。结果两院泌尿外科224例医院感染患者发生感染259例次,泌尿道、呼吸道是感染好发部位,分别占45.2%、17.8%;共分离出301株病原菌,以革兰阴性菌为主,共207株占68.8%;病原菌对临床常用抗菌药物产生了不同程度的抗药性;MRSA的分离率为46.2%;泛耐药铜绿假单胞菌和鲍氏不动杆菌检出率分别达12.9%与20.0%;产ESBLs菌分离率为53.8%。结论医院领导应进一步加大抗菌药物监督管理执行力度,切实扭转鄂州市抗菌药物应用不规范导致病原菌耐药的不良倾向。
OBJECTIVE To discuss antimicrobial resistance profiles and clinical distribution of pathogenic bacteria causing nosocomial infections in department of urinary surgery in two hospitals in Ezhou city, and provide reference for clinical prevention and control of it. METHODS A retrospective review was performed on 224 cases of nc/socomial infections from Jan. 2011 to Jun. 2014 to analyze infection sites and pathogenic distribution. Data were statistically analyzed by software WHONET 5.6. RESULTS During three years, there were 259 case-times of infection in the 224 cases of nosocomial infections. The infection sites mostly were urinary tract （45.2 %） and respiratory tract （17.8 %）. Totally 301 pathogenic bacteria strains were isolated, dominated by gram-negative bacteria accountifig for 68.8M. Pathogenic bacteria were resistant to commonly used antibiotics in varying degrees. The isolating rates of methicillin-resistant Staphylococcus aureus （MRSA） were 46. 2%. Those of pan-resistant Pseudomonas aeruginosa and Acinetobacter baumannil were 12.9 % and 20.0 %. 53.8% strains were ESBLs-pro- ducers. CONCLUSION Hospitals should perform management of antibiotic usage to reverse the increasing tendency of antimicrobial resistance caused by non-standard use of antibiotics.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第24期5660-5662,共3页
Chinese Journal of Nosocomiology
基金
湖北省自然科学基金资助项目(2011CDB501)
关键词
泌尿外科
医院感染
临床
病原菌
Department of urinary surgery
Nosocomial infection
Clinic
Pathogenic bacteria
