摘要
目的探讨IL-32、IL-6和IL-8水平预测慢加急性乙型肝炎肝衰竭(HBV-ACLF)患者预后的价值。方法采用ELISA法检测62例慢性乙型肝炎(A组)、68例HBV-ACLF(B组)及20例健康对照(C组)血清IL-32、IL-6和IL-8水平,分析其与ALT、AST、TBil、Alb、PT的相关性,探讨其预测HBV-ACLF患者预后的价值。结果 A、B组血清IL-32和IL-8水平均高于C组,而血清IL-6水平低于C组(P<0.01);B组血清IL-32和IL-6水平高于A组,而血清IL-8水平低于A组(P<0.01);取910.8pg/ml作为血清IL-32最佳界值时,其预测B组患者短期预后的灵敏度为88.77%,特异性为78.00%。结论 IL-32、IL-6、IL-8均能反映慢性乙型肝炎和HBV-ACLF患者肝脏炎症损伤和病情严重程度,但在对HBV-ACLF患者预后评估方面,仅IL-32有一定的预测价值。
Objective To explore the value of serum IL‐32 ,IL‐6 and IL‐8 in predicting the prognosis of the patients with acute‐on‐chronic liver failure by hepatitis B virus （HBV‐ACLF ） . Methods Serum levels of IL‐32 ,IL‐6 and IL‐8 were detected by ELISA in 62 patients with chronic hepatitis B（group A） ,68 patients with HBV‐ACLF（group B） and 20 healthy controls（group C） . ALT ,AST ,TBil ,Alb and PT were examined as well .The correlation of serum IL‐32 ,IL‐6 and IL‐8 levels and the prognosis of the patients with HBV‐ACLF was analyzed .Results Serum levels of IL‐32 and IL‐8 were higher ,but serum IL‐6 level was lower ,in groups of A and B than those in group C （P〈0 .01） .Serum levels of IL‐32 and IL‐6 were higher ,but serum IL‐8 level was lower ,in group B than those in group A （ P〈0 .01 ） .Taking 910.8 pg/ml as the cutoff value of serum IL‐32 ,the sensitivity and specificity were 88.77% and 78.00% ,respectively .Conclusion Serum levels of IL‐32 , IL‐6 and IL‐8 can reflect the severity of liver inflammation injury and illness in the patients with chronic hepatitis B and HBV‐ACLF .But only serum level of IL‐32 has a certain value in predicting the prognosis of the patients with HBV‐ACLF .
出处
《江苏医药》
CAS
2015年第23期2847-2850,共4页
Jiangsu Medical Journal
基金
南通市社会发展项目(HS20120019)
