摘要
目的检测类风湿性关节炎（RA）患者血清IL-33的表达，分析其与类风湿因子（RHF）和C反应蛋白（CRP）的相关性．探讨IL-33的表达水平与疾病严重程度的关系。方法采用酶联免疫吸附法（ELISA）检测24例活动期RA病人血清IL-33的表达水平，以25例正常人作为对照；检测RA患者风湿四项的实验室指标；分析RA患者IL-33与RHF和CRP的相关性：结果RA患者血清IL-33的表达明显高于正常对照（P〈0．01）；风湿四项的指标申100％（24人）患者的RHF值、79．17％患者（19人）的CRP和75％患者（18人）的ESR（红细胞沉降率）高于正常；患者IL-33的表达与RHF和CRP成正相关关系。结论IL-33在RA患者的发病过程中发挥重要作用，与疾病严重程度相关，可为RA病情的判断提供新的检测指标。
Objective T. detect the changes of serum IL-33 in patients with rhetmlatoid arthritis （RA） and to analyze the correlation be-tween IL - 33 leves and RHF/CRP. To explore the relationship between the changes of IL - 33 levels and the severity of RA. Methods Serum IL-33 levels were determined in 24 patients with RA and 24 healthy individuals by enzyme - linked immuno - sorbent assay （ELISA） method; Four laboratou, parameters of RA cases were recorded; then the correlations between the levels of IL- 33 and RHF/CRP were ana-lyzed. Results Significant difference for serum IL - 33 levels was existed tretween RA patients and normal controls （P 〈 0. 01 ）. The levels of RHF in 24 patients with RA were higher than normal values, while 19 cases of CRP levels and 18 cases of ESR levels were increased, The positive correlation was found between the levels of IL - 33 and RHF/CRP. Conclusion IL - 33 plays a role in the development of RA and be related to the severity of this disease. Monitoring IL - 33 levels changes is helpful for assessments of RA disease.
出处
《医学检验与临床》
2012年第3期54-56,共3页
Medical Laboratory Science and Clinics
基金
深圳市科技研发资金-基础研究项目
