长链非编码RNA、微小RNA与表观遗传学相互作用关系的研究进展
被引量:3
摘要
表观遗传是指DNA序列不发生变化而基因表达却发生了可遗传的改变,涉及的分子机制主要包括DNA甲基化、组蛋白修饰、染色质重塑,广义上还包括非编码RNA。长链非编码RNA(IncRNA)和微小RNA(microRNA,miRNA)是真核细胞生物中两类很重要的非编码RNA,不仅自身的表达受到表观遗传的调节,而且还能对表观遗传的其他方面发挥重要的调控作用。IncRNA参与X染色体沉默、基因组印记、
出处
《中华病理学杂志》
CAS
CSCD
北大核心
2015年第12期926-928,共3页
Chinese Journal of Pathology
基金
国家自然科学基金(81472326)
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