摘要
柯萨奇病毒A组2型(CV-A2)是引起手足口病和疱疹性咽峡炎暴发流行的重要病原体。本文选取中国大陆流行的D基因型代表毒株JS16-80/JS/CHN/2016(简写JS16-80)进行全基因组序列测定和分析,了解其基因特征,并进行重组和进化分析。结果提示,JS16-80在非结构蛋白P2和P3多区段均有出现重组现象,并且多个A组肠道病毒血清型参与了非结构蛋白的重组。本研究可帮助了解CV-A2的全基因组特征和重组特点,进一步为CV-A2重组对其进化和潜在致病力的影响提供基础数据。
Coxsackievirus A2(CV-A2)is an important pathogen that causes outbreaks of hand,foot,and mouth disease(HFMD)and herpangina.We report the complete genome sequence of a CV-A2 strain,JS16-80/JS/CHN/2016(abbreviated as"JS16-80"),which is the representative of genotype D of CV-A2 in China's Mainland.We wished to study its genetic characteristics,evolution and recombination.The phylogenetic tree and Simplot analysis showed that frequent recombination occurred in the P2 and P3 regions within enterovirus A.Our study will help understanding of the genomic characteristics and recombinant variation of CV-A2,and to provide basic information on recombinant influence on evolution and potential pathogenicity.
出处
《病毒学报》
CAS
CSCD
北大核心
2018年第5期512-518,共7页
Chinese Journal of Virology
基金
十三五国家科技重大专项(项目号:2018ZX10713002)
题目:病毒性传染病病原谱和病毒基因变异变迁规律研究
十三五国家科技重大专项(项目号:2017ZX10104001)
题目:基于全基因组的病毒网络化监测和溯源技术体系研究~~
