摘要
目的开展百日咳和白喉胎传抗体及百白破疫苗接种的免疫成功率监测,为百日咳和白喉预防接种策略的调整提供科学依据。方法选择2013年1月-2月在天津市滨海新区出生并计划将长期居住的132名新生儿,开展胎传抗体及其衰减情况以及百白破疫苗免疫成功率监测。采集脐带血,监测新生儿百日咳Ig G抗体和白喉Ig G抗体及其衰减情况;采集静脉血,监测新生儿接种完3剂百白破疫苗后,间隔1个月百日咳Ig G抗体和白喉Ig G抗体水平。结果百日咳、白喉胎传抗体阳性率分别为31.06%、33.33%;3月龄时百日咳、白喉胎传抗体的转阴率分别为89.19%、94.59%;接种3针百白破疫苗后1个月,百日咳、白喉的免疫成功率分别为76.67%、100.00%。结论百日咳和白喉胎传抗体阳性率低并且转阴快,3月龄前婴儿感染百日咳风险很高;百日咳基础免疫后免疫成功率相对较低。
Objective To monitor the antibodies for pertussis and diphtheria,as well as the immune success rates of DPT vaccination,so as to provide scientific basis for the adjustment of prevention and vaccination strategies on pertussis and diphtheria.Methods The umbilical cord blood and venous blood samples were collected from 132 infants resided in Binhai New Area from January to February in 2013,respectively for the monitoring of neonatal pertussis and diphtheria Ig G antibodies and their attenuation,and for the monitoring of them in the second month after 3 doses of DPT vaccination,on whom the monitoring of fetal transmission antibody and its attenuation,as well as the success rate of DPT vaccination were carried out. Results The positive rates of fetal transmission antibodies for pertussis and diphtheria were respectively 31. 06% and 33. 33%. The converting rates from positive to negative of them were respectively 89. 19% and 94. 59% at three-month age. The immune success rates of pertussis and diphtheria were respectively 76. 67% and 100. 00% in one month after DPT vaccination. Conclusion The positive rates of fetal transmission antibodies for pertussis and diphtheria are low,and the converting to negative is fast,so babies who aged ≤3 months have a high risk of pertussis infection. The immune success rate of pertussis after basic immune is relatively low.
出处
《中国卫生检验杂志》
CAS
2015年第23期4126-4127,4130,共3页
Chinese Journal of Health Laboratory Technology
关键词
百日咳
白喉
胎传抗体
监测
Pertussis
Diphtheria
Fetal transmission antibody
Monitoring
