摘要
目的探讨二甲双胍对2型糖尿病合并乙型病毒性肝炎（简称乙肝）患者病毒复制和肝功能的影响。方法将82例有乙肝病史的新诊断2型糖尿病患者随机分为二甲双胍组（40例）和非二甲双胍治疗组（42例）进行降血糖治疗；在开始降血糖治疗前和治疗3个月后检测患者血压、身高、体重、腰围、肝功能、血脂、血糖、胰岛素、乙肝DNA、乙肝血清学等一般临床资料和生化指标并进行分析比较。结果二甲双胍组和非二甲双胍组均可明显改善患者血糖和B细胞功能（P〈0．05）。二甲双胍组在改善腰围、甘油三酯、BMI和胰岛素敏感指数方面优于非二甲双胍组（P〈0．05）。同时二甲双胍对肝功能和乙肝病毒复制无明显作用，与非二甲双胍组差异尢统计学意义。结论二甲双胍用于无严重并发症的2型糖尿病合并乙肝患者较为安全有效。
Objective To evaluate the effect of metformin treatment on viral replication and liver function in type 2 diabetes with hepatitis B patients. Methods Eighty two newly diagnosed type 2 diabetes patients with a history of hepatitis B, were randomly divided into 2 groups for anti-hyperglycemic treatment ： metformin group and non-metformin group（40 vs. 42）. The patients were examined or tested for general clin- ical and biochemistry index at the initiation of the study and three months after. Results Both metformin group and non-metformin group can significantly improve blood sugar and [^-cell function （ P 〈 0.05 ）. However,metformin is superior to non-metformin group in reducing WC, triglycerides, BMI and insulin sensitivity（ P 〈0. 05 ）. Meanwhile, no significant effect on liver function and hepatitis B viral replication was observed in both groups. Conclusion Metformin is safe for simple type 2 diabetes patients with hepatitis B.
出处
《临床内科杂志》
CAS
2015年第11期758-760,共3页
Journal of Clinical Internal Medicine
基金
国家自然科学基金资助面上项目（81170767、81571376）
中国糖尿病英才研究基金项目
中华医学会糖尿病科研基金项目（13060906481）
