摘要
目的探讨血浆脂蛋白相关性磷脂酶A2（lipoprotein-associated phospholipase A2,Lp-PLA2）浓度与冠状动脉粥样硬化性心脏病（冠心病）严重程度的相关性。方法采用横断面研究方法,入选从2013年至2014年在广东省人民医院住院并行冠状动脉造影检查的研究对象共678例。收集所有入选患者的人口学资料、实验室数据以及冠状动脉造影检查结果。依据冠状动脉造影检查结果,将所有入选者分为对照组（排除冠心病）、非严重狭窄组（冠状动脉狭窄〈50%）、单支病变组（单支冠状动脉狭窄〉50%）以及多支病变组（两支或三支冠状动脉狭窄〉50%）。依据上述分组,对各组入选患者的基线资料进行比较,同时采用多因素方差分析血浆Lp-PLA2浓度与冠状动脉病变支数的相关性。明确血浆Lp-PLA2浓度与冠状动脉病变支数是否具有独立相关性。结果 （1）与其他组相比,多支病变组患者男性所占比例较高、吸烟人数较多、血浆脂蛋白（a）浓度和Lp-PLA2浓度较高,而原发性高血压（高血压）患者比例以及血浆高密度脂蛋白胆固醇和载脂蛋白A浓度较低,差别具有统计学意义（P〈0.05）。其余各变量各组间比较,差异无统计学意义（P〉0.05）。（2）多因素回归分析结果显示,校正传统因素如年龄、性别、吸烟、高血压、糖尿病、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白A和载脂蛋白B浓度后,血浆Lp-PLA2浓度与冠状动脉病变支数仍具有独立相关性（OR=1.053,95%CI：1.025~1.069,P〈0.05）。结论血浆Lp-PLA2浓度与冠状动脉病变程度具有一定的相关性,动态检测血浆Lp-PLA2浓度可用于评估冠状动脉病变的进展。
Objectives To investigate the relationship between plasma concentration of lipoprotein-associated phospholipase A2（Lp-PLA2） and the severity of coronary artery diseases（CAD）. Methods Cross-sectional research was performed and totally 678 participants were enrolled and performed coronary angiography（CAG） from 2013 to 2014 in Guangdong General Hospital to figure out the number of coronary artery stenosis. According to CAG results,participants were divided into control（excluded CAD）, non-significant stenosis（〈 50 %）, single vessel stenosis（ 〉50%）and multi-vessel stenosis（two or three vessels〉 50 %） groups. Baseline characteristics were recorded and compared.Statistical analyses including multivariate regression analyses were performed to evaluate the relationship between plasma concentration of Lp-PLA2 and CAD severity. Results（1）Compared to the other groups, male patients and the percentage of patients with smoking were more in multi-vessels group,and plasma concentrations of lipoprotein（a） and LpPLA2 were also higher in multi-vessels group. In contrast,the percentage of patients with hypertension and plasma concentrations of high-density lipoprotein cholesterol（HDL-C） and Apolipoprotein A（Apo A） were lower. All the differences between groups were significant（P〈0.05）. And other variables between groups were insignificant（P〈0.05）.（2）Multivariate regression analyses revealed that, after adjusting to traditional risk factors including age, gender,smoking, hypertension, diabetes mellitus, low-density lipoprotein cholesterol（LDL-C）, HDL-C, Apo A and Apo B,LpPLA2 was still significantly associated with the number of CAD, and the odd ratio was 1.053（multiple-vessels stenosis group versus control group, 95 % CI 1.025-1.069, P〈0.05）. Conclusions Plasma concentration of Lp-PLA2 is independently associated with the severity of CAD, and it may be used to evaluate the development of CAD.
出处
《岭南心血管病杂志》
2015年第5期587-589,600,共4页
South China Journal of Cardiovascular Diseases
关键词
冠状动脉疾病
脂蛋白相关性磷脂酶A2
相关性
coronary artery disease
lipoprotein-associated phospholipase A2
relationship
