摘要
目的探讨血细胞常规、C反应蛋白（CRP）和降钙素原（PCT）联合检测在诊断儿童病毒感染性疾病的临床意义。方法选取2014年10~12月因急性呼吸道感染住院治疗患儿80例,应用直接免疫荧光法检测7种呼吸道病毒抗原,比较40例腺病毒（ADV）感染阳性患儿（ADV组）及40例呼吸道合胞病毒（RSV）感染阳性患儿（RSV组）的血细胞常规、CRP及PCT检测结果。结果与RSV组比较,ADV组患儿白细胞（WBC）计数升高,差异有统计学意义（P〈0.05）,其中RSV组以淋巴细胞为主[（63.4±13.5）%],ADV组以中性粒细胞为主[（62.9±14.7）%];而两组单核细胞百分比比较,差异无统计学意义（P〉0.05）。ADV组患儿CRP水平高于RSV组,差异有统计学意义（P〈0.05）;而两组PCT水平均未见明显升高,差异无统计学意义（P〉0.05）。结论儿童不同病毒感染性疾病的血细胞常规和CRP水平存在明显差异,应用血细胞常规、CRP及呼吸道病毒抗原联合检测鉴别诊断儿童病毒感染性疾病,对疾病的早期确诊及对症治疗具有重要的临床意义。
Objective To explore the clinical significance of joint detection of blood routine test,C reactive protein（CRP）and procalcitonin（PCT）in diagnosis of virus infectious disease in children.Methods A total of 80 cases of in-patient children diagnosed with acute respiratory infection from October to December 2014 were collected,and the seven antigens of respiratory viruses were detected by using direct immunofuorescence assay.The results of blood test,CRP and PCT levels were compared between 40 cases of children with adenovirus（ADV）infection（ADV group）and 40 cases of children with respiratory syncytial virus（RSV）infection（RSV group）.Results Compared with the RSV group,the white blood cell（WBC）count was increased in the ADV group,there was statistically significant difference（P〈0.05）.The highest percentage of WBC in RSV group was lymphocyte[（63.4±13.5）%],and the highest percentage of WBC in ADV group was neutrophil[（62.9±14.7）%].While no statistically significant difference was found in the percentage of mononuclear cell between the two groups（P〈0.05）.The level of CRP in ADV group was significantly higher than that in RSV group,there was statistically significant difference（P〈0.05）,while there was no statistically significant difference in the level of PCT between the two groups（P〈0.05）.Conclusion There are significant differences in results of blood routine test and level of CRP between children with different virus infectious disease.Combined determination of blood routine test,CRP and respiratory virus antigen detection has important clinical significance in early diagnosis and treatment of viral infectious diseases.
出处
《国际检验医学杂志》
CAS
2015年第23期3390-3392,共3页
International Journal of Laboratory Medicine
基金
深圳市儿童医院重症疾病诊断重点实验室资助项目[深发改(2012)866号]
