摘要
目的探讨慢性阻塞性肺疾病(COPD)急性加重期患者肺部感染应用噻托溴铵治疗的效果,为临床治疗提供参考。方法随机选取2013年1月-2014年9月在医院接受治疗的慢性阻塞性肺疾病急性加重期并伴有轻、中度的肺部感染患者共80例作为研究对象,将其分为观察组和对照组各40例;对照组患者给予常规的治疗,观察组患者在此基础上联合噻托溴铵进行治疗,分析两组患者治疗效果,数据采用SPSS 18.0软件进行统计分析。结果两组患者治疗前的氧合指数(PaO2/FiO2)以及动脉血二氧化碳分压(PaCO2)水平比较差异无统计学意义,治疗后,观察组患者的氧合指数(PaO2/FiO2)明显高于对照组,而动脉血二氧化碳分压(PaCO2)明显低于对照组,两组比较差异有统计学意义(P<0.05);观察组患者治疗的总有效率达到97.5%,明显高于对照组,两组比较差异有统计学意义(P<0.05)。结论对于肺部感染的COPD急性加重期患者采用噻托溴铵进行治疗的效果显著,可以使肺功能得到显著改善,值得在临床上广泛使用并推广。
OBJECTIVE To investigate the curative effect of tiotropium in the treatment of pulmonary infections in patients on acute exacerbations of chronic obstructive pulmonary disease （COPD） so as to provide references for clinical treatments. METHODS A total of 80 cases with light or moderate pulmonary infections on acute exacerba- tions of chronic obstructive pulmonary disease were randomly selected from Jan. 2013 to Sep. 2014 as study ob- jects. They were divided into observation group and control group with 40 cases in each group. The control group was given routine therapy and the observation group adopted tiotropium on the basis of routine therapy. The clini- cal effects of the two groups were statistically analyzed by SPSS 18.0 software. RESULTS The oxygenation index （PaO2/ FiO2 ） and arterial carbon dioxide tension （PaCOz） of the two groups before treatments showed no signifi- cant difference in levels （P〉0.05）, but after treatments, the observation group had a higher oxygenation index （PaO2/FiO2） than the control group, while partial pressure of carbon dioxide in artery （PaCO2） was significantly lower than the control group（P〈0.05）. The total effective rate of the observation group was 97.5%, significant- ly higher than the control group （P〈0.05）. CONCLUSION Lung infections in patients with acute exacerbation of COPD can be effectively cured by using tiotropium, which can remarkably improve lung function and should be widely used in clinical practice.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第23期5401-5403,共3页
Chinese Journal of Nosocomiology
基金
山东省科技厅研究基金资助项目(SD12447-02456)
