摘要
目的 探究食管癌术后伴HBV感染患者应用恩替卡韦药物治疗对肝功能的影响以及整体护理的效果.方法 选用自2008年4月到2014年1月来我院救治的食管癌术后伴HBV感染患者105例作为研究对象,其中31例（29.52％）分为研究组,在整体护理的基础上采用口服恩替卡韦抗病毒药物治疗;74例（70.48％）分为对照组,采用常规护理,未接受任何抗病毒药物治疗.治疗结束后,记录两组患者住院时间并检测两组患者肝功能指标,对患者进行1年内随访,观察肝炎以及肝衰竭发生状况.结果 在谷丙转氨酶、谷草转氨酶、总胆红素、间接胆红素和前白蛋白含量方面,两组患者治疗后均存在显著统计学差异（P＜0.05）.虽然研究组患者住院时间短于对照组患者,但两组之间无差异（P＞0.05）.研究组患者肝炎发病率为12.90％ （4/31）,对照组患者肝炎发病率为36.47％（27/74）,存在统计学差异（x2=5.840,P=0.016＜0.05）.对照组患者肝衰竭死亡率为4.05％ （3/74）,研究组无肝衰竭现象发生.结论 食管癌术后伴HBV感染应用恩替卡韦治疗效果显著,能降低肝炎和肝衰竭发病率,临床可以作为治疗措施进行推广.
Objective To evaluate the therapeutic and nursing effects of entecavir for patients complicated with HBV infection after esophageal carcinoma surgery.Methods One hundred and five patients who received esophageal carcinoma surgery and acquired HBV infections from April 2008 to January 2014 in our hospital were chosen as the research subjects.Thirty-one cases （29.52%） were assigned into the study group and were treated with oral administration of entecavir antiviral therapy on the basis of the overall nursing.seventy-four cases （70.48%） were assigned into the control group,which were treated with routine nursing without any antiviral drugs.At the end of treatment,hospitalization time and liver function parameters of two patient groups were recorded and analyzed.Results The alanine aminotransferase,aspartate aminotransferase,total bilirubin,indirect bilirubin and prealbumin levels before and after treatment showed significant differences between both groups（P 〈 0.05）.Though hospitalization time of study group was shorter than that of the control group,there was no statistically significant difference between both groups （P 〉0.05）.The incidence of hepatitis in the study group was 12.90% （4/3 1） and 36.47% （27/74） in the control group.The difference was statistically significant （x2 =5.840,P =0.016 〈 0.05） between both groups.The mortality of liver failure in the control group was 4.05% （3/74） and there was no case of liver failure in the study group.Conclusions For the treatment of HBV infection in patients after esophageal carcinoma surgery,entecavir effect was remarkable because of reducing the incidence of hepatitis and liver failure rate,which was valuable to be applied extensively.
出处
《国际病毒学杂志》
2015年第4期288-288,I0001-I0003,共4页
International Journal of Virology
关键词
食管癌
恩替卡韦
护理
HBV
Esophageal carcinoma
HBV
Entecavir
Nursing
