摘要
目的:观察还原型谷胱甘肽注射液对小儿肺炎合并肝功能损害的疗效。方法:选取确诊为儿童肺炎合并肝功能损害的患儿147例,随机分为观察组75例对照组72例。对照组给予常规治疗,观察组在常规治疗的基础上加用还原型谷胱甘肽注射液(阿拓莫兰)30 mg/(kg·d)静脉滴注,1次/天,两组分别于治疗前及治疗7 d后测定肝功能并比较。结果:治疗后两组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平较治疗前显著降低(P<0.05),观察组ALT、AST较对照组下降更明显(P<0.05),而两组治疗前后谷酰转肽酶(GGT)、总胆汁酸(ALP)、碱性磷酸酶(TBA)水平无明显下降(P>0.05)。结论:在常规治疗基础上加用还原型谷胱甘肽注射液治疗小儿肺炎合并肝功能损害可更快地恢复肝功能,值得临床推广应用。
Objective： To investigate the effect of glutathione injection in children with pneumonia complicated by liver dysfunction.Methods： One hundred and forty seven children diagnosed with pneumonia and liver dysfunction were randomly divided into two groups,the control group（ 75 cases） and the observation group（ 72 cases）. On the basis of conventional therapy,glutathione injection（ Atomolan） was given 30 mg/（ kg·d） intravenously,once a day. The control group received conventional treatment. Liver function was measured before treatment and after 7 days＇ treatment. Results： After treatment,the levels of alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST） compared with before treatment were significantly lower（ P〈0. 05）. The levels of ALT,AST decreased more significantly in the observation group than the control group（ P〈0. 05）,and GGT,ALP,TBA had no significant decrease. Conclusion： The effect of glutathione injection in the treatment of infantile pneumonia combined liver dysfunction is better.
出处
《儿科药学杂志》
CAS
2015年第12期29-31,共3页
Journal of Pediatric Pharmacy
