摘要
目的观察不同配比的芍药甘草丸对利培酮所致女性精神分裂症患者血清催乳素的影响。方法 120例患者随机分为A组40例(利培酮)、B组40例(芍药∶甘草=1∶1,利培酮)、C组40例(芍药∶甘草=2∶1,利培酮),观察治疗前、治疗4周、治疗8周、治疗12周后3组患者血清催乳素水平变化,采用阳性与阴性症状量表(PANSS)评定治疗前后效果,采用副反应量表(TESS)评定治疗前后药物不良反应。结果治疗4周、8周、12周后,B组、C组与A组患者比较,血清催乳素水平均明显下降(P<0.05),C组与B组患者比较,血清催乳素水平均明显下降(P<0.05)。提示芍药甘草丸(芍药∶甘草=2∶1)相对于芍药甘草丸(芍药∶甘草=1∶1)可以更大程度地降低女性精神分裂症患者血清催乳素水平。结论芍药甘草丸能降低抗精神病药利培酮所致女性精神分裂症患者血清催乳素水平,但芍药甘草丸尤以2∶1的配比能最大程度地降低血清催乳素水平,且不影响抗精神病药利培酮的临床疗效。
Objective To observe the effects of peony licorice bolus of risperidone with different proportions on female schizophrenia patients suffered hyperprolactinemia induced by risperidone. Methods 120 patients were randomly divided into group A （Risperidone）, group B （Peony ： licorice 1 ： 1, Risperidone）, group C （Peony ： licorice 2 ： 1, Risperidone）. The change of serum levels of prolactin, estradiol, testosterone, follicle stimulating hormone, luteinizing hormone, progesterone were observed before and after treatment for 4, 8 and 12 weeks. Positive and negative symptom scale were used to evaluate the effect of treatment before and after treatment. Adverse drug reactions were evaluated by using the side reaction scale before and after treatment. ResultsCompared with group B and group 12, the serum of prolactin levels of group A were significantly decreased（P〈0.05）. Compared with group B the serum of prolactin levels of group C were significantly decreased （P〈0.05）, which suggested that the serum levels of prolactin in female patients with schizophrenia could be reduced by a greater degree thala 2 - 1 that of 1 ： 1. Conclusion The peony and licorice pill can obviously reduce serum prolactin levels of risperldone but the ratio is 2 ： 1 to the maximum extent of the serum prolactin levels of the peony and licorice pills.
出处
《医学研究与教育》
CAS
2015年第5期35-38,共4页
Medical Research and Education
关键词
不同配比
芍药甘草丸
利培酮
高催乳素血症
different proportions
the peony and licorice pill
risperidone
high prolactin
