摘要
目的比较哌罗匹隆与氟哌啶醇治疗老年精神分裂症患者的临床疗效及安全性。方法选取攀枝花市第三人民医院2012—2014年收治的精神分裂症患者64例,按照随机数字表法分为试验组和对照组,每组32例。试验组患者给予哌罗匹隆治疗,对照组患者给予氟哌啶醇治疗。比较两组患者临床疗效及不良反应发生情况,治疗前及治疗4、6、8周阳性与阴性症状量表(PANSS)评分,并观察两组患者合并用药情况。结果 64例患者中完成研究者62例,两组各有1例患者因依从性差而脱落。两组患者临床疗效比较,差异无统计学意义(u=-0.049,P=0.961)。治疗前及治疗4、6、8周两组患者阴性症状量表评分、阳性症状量表评分、一般精神病理症状量表评分及PANSS总分比较,差异无统计学意义(P>0.05);治疗4周两组患者阳性症状量表评分、一般精神病理症状量表评分及PANSS总分均低于治疗前,治疗6、8周两组患者阴性症状量表评分、阳性症状量表评分、一般精神病理症状量表评分及PANSS总分均低于治疗前(P<0.05)。试验组患者锥体外系反应发生率低于对照组(P<0.05);两组患者嗜睡、记忆力下降、恶心呕吐、心率加快、失眠、视物模糊、头晕、便秘发生率比较,差异无统计学意义(P>0.05)。试验组4例、对照组3例患者因失眠导致焦虑、紧张而使用苯二氮卓艹类药物,均未使用抗胆碱能药物。结论哌罗匹隆与氟哌啶醇治疗老年精神分裂症的临床疗效相当,但哌罗匹隆引起的锥体外系反应发生率较低,患者依从性更好。
Objective To compare the clinical effect and safety on senile schizophrenia between perospirone and haloperidol.Methods A total of 62 aged patients with schizophrenics were selected in the Third People＇s Hospital of Panzhihua from 2012 to 2014,and they were divided into control group and test group,each of 32 cases.Patients of control group received haloperidol,while patients of test group received perospirone.Clinical effect,incidence of adverse reactions,PANSS score before treatment and 4,6,8 weeks of treatment were compared between the two groups,and drug combination was observed.Results One of control group and one of test group lost caused by poor compliance.No statistically significant differences of clinical effect was found between the two group（u =-0.049,P = 0.961）.No statistically significant differences of Negative Symptoms Rating Scale score,Positive Symptoms Rating Scale score,General Mental Pathological Symptoms Scale score or total PANSS score was found between the two groups before treatment or 4,6,8 weeks of treatment（P〉0.05）; after 4 weeks of treatment,Positive Symptoms Rating Scale score,General Mental Pathological Symptoms Scale score and total PANSS score of both groups were statistically significantly lower than those before treatment（P〈0.05）; after 6 and 8 weeks of treatment,Negative Symptoms Rating Scale score,Positive Symptoms Rating Scale score,General Mental Pathological Symptoms Scale score and total PANSS score of both groups were statistically significantly lower than those before treatment（P〈0.05）.The incidence of extrapyramidal reactions of test group was statistically significantly lower than that of control group（P〈0.05）,while no statistically significant differences of incidence of sleepiness,memory deterioration,nausea and vomiting,increased heart rate,insomnia,blurred vision,dizziness orconstipation was found between the two groups（P〉0.05）.Three cases of control group,four cases of test group used benzodiazepines because of insomnia-induced
出处
《实用心脑肺血管病杂志》
2015年第10期88-91,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
精神分裂症
哌罗匹隆
氟哌啶醇
疗效比较研究
Schizophrenia
Perospirone
Haloperidol
Comparative effectiveness research
