摘要
目的:分析慢性鼻-鼻窦炎(CRS)患者外周血补体C3、C4的变化及其与CRS的关系。方法:回顾性分析2012年3月至2014年5月本科收治的188例CRS手术患者的临床资料,其中不伴鼻息肉组(CRSs NP)97例、伴鼻息肉组(CRSw NP)91例;选取同期本院体检中心的58例健康体检者(无既往疾病史)作为对照组。检测外周血补体C3、C4水平,并与CRS患者的临床资料进行相关分析。结果:28例(28.87%)CRSs NP患者、35例(38.46%)CRSw NP患者外周血C3水平下降,两组比较,差异无统计学意义(P>0.05),但均明显高于正常对照组(3例,5.17%,P<0.05)。37例(38.14%)CRSs NP、49例CRSw NP(53.84%)患者外周血C4水平下降,两组比较,差异有统计学意义(P<0.05),且均高于正常对照组(2例,3.45%,P<0.05)。CRSs NP和CRSw NP患者外周血C3和C4水平均成正相关(r=0.412,0.418,P<0.05);CRSw NP患者外周血C3与中性粒细胞数及CT评分具有明显的相关性(r=0.260,P<0.05)。结论:补体系统可能在CRS的发病机制中发挥重要作用,不同亚型的CRS中补体系统的活化途径存在差异。
Objective： To investigate the changes of complement C3 and C4 in peripheral blood（ PB） of patients with chronic rhinosinusitis（ CRS） and its correlation with CRS. Methods： The clinical data of 188 CRS patients hospitalized in our deparment between March 2012 and May 2014 were retrospectively analyzed,and divided into the CRS without nasal polyps（ CRSs NP） group（ n = 97） and the CRS with nasal polyps（ CRSw NP） group（ n = 91）. A contemporary cohort of 58 healthy subjects（ no previous medical history） examined in our physical examination center was included in the control group. The complement C3 and C4 levels in PB were determined for correlation analysis with the clinical data of the CRS patients. Results： The C3 level in PB of 28 CRSs NP patients（ 28. 87%） and 35 CRSw NP patients（ 38. 46%） were decreased without statistically significant differences（ P〈0. 05）,and were significantly higher than that in the control normal group（ 3 cases,5. 17%,P〈0. 05）. The C4 level in PB of 37 CRSs NP patients（ 38. 14%） and 49 CRSw NP patients（ 53. 84%） were decreased with statistically significant differences（ P〈0. 05）,and were significantly higher than that in the control normal group（ 2 cases,3. 45%,P〈0. 05）. The C3 and C4 levels in PB of CRSs NP and CRSw NP were positively correlated（ r = 0. 412,0. 418,P〈0.05）. Significant correlation was found between C3 level in PB,neutrophil and CT score in CRSw NP patients（ r =0. 60,P〈0. 05）. Conclusion： The complement system may play an important role in the pathogenesis of CRS.There are activation pathways in the complement system of different subtypes of CRS.
出处
《广州医科大学学报》
2015年第4期9-11,15,共4页
Academic Journal of Guangzhou Medical University
基金
国家自然科学基金(81200732)
广东省自然科学基金(S2012040006823)
