摘要
目的探讨益气健脑方联合针刺治疗恢复期缺血性脑卒中疗效及对患者内皮素-1(ET-1)与降钙素基因相关肽(CGRP)水平的影响。方法 120例符合纳入标准的缺血性脑卒中恢复期患者随机分为两组,每组各60例。对照组给予针刺疗法,观察组在对照组的基础上联合使用益气健脑方。观察比较两者患者临床疗效、中医证候评分、神经功能缺损评分、痉挛程度评分、并发症发生、两组患者ET-1与CGRP水平、以及生活质量和不良反应发生情况。结果观察组的总治疗有效率为93.3%,明显高于对照组78.3%的总治疗有效率,两组比较差异有统计学意义(P<0.05)。治疗后,观察组在改善中医证候、神经功能缺损及痉挛方面明显优于对照组,两组比较差异有统计学意义(P<0.05)。观察组治疗后发生肩关节脱位、肩手综合征、足下垂、足内翻及关节痉挛并发症的例数明显少于对照组,两组比较差异有统计学意义(P<0.05)。观察组治疗后ET-1水平显著低于对照组,CGRP水平显著高于对照组,差异有统计学意义(P<0.05)。生活质量方面,治疗后,与对照组比较,观察组躯体功能、躯体角色、机体疼痛、总的健康、活力、社会功能及心理卫生评分明显增加,两组比较差异有统计学意义(P<0.05),而情绪角色评分在两组之间比较差异无统计学意义(P>0.05)。治疗过程中,对照组和观察组过敏不良反应发生率分别为6.7%和5.0%,组间比较差异无统计学意义(P>0.05)。结论益气健脑方联合针刺是治疗缺血性脑卒中恢复期的有效治疗方案,可以显著提高治疗有效率,改善患者中医证候、神经功能及痉挛程度,降低并发症发生率,降低ET-1并升高CGRP水平,明显提高患者的生活质量,且不良反应少,值得临床上进一步研究及推广。
【Objective】 To investigate the clinical effect of Yiqi Jiannao Decoction plus acupuncture in treating ischemic apoplexy in recovery stage and its effects on serum levels of endothelin-1（ET-1） and calcitonin gene related peptide（CGRP）.【Methods】 Totally 120 cases in recovery stage of ischemic apoplexy meeting the inclusion criteria were randomly divided into two groups with equal number.The cases of the control group were treated with acupuncture and those of the observation group were treated with Yiqi Jiannao Decoction plus acupuncture.Then,the curative efficacy,traditional Chinese medicine（TCM） syndrome evaluation,neurological deficit scores,spasm degree estimated by Ashworth score,occurrence of complications,serum levels of ET-1 and CGRP,life quality and incidence of adverse reactions were observed and compared be-tween both groups.【Results】 The observation group had a total therapeutic rate of 93.3%,which was statistically higher than that of 78.3% in the control group（P〈0.05）.After treatment,the TCM syndrome,neurological deficit scores and Ashworth score were statistically improved in the observation group in comparison to the control group（P〈0.05）.There were statistically fewer cases with shoulder dislocation,shoulder-hand syndrome,foot drop,strephenopodia and articular spasm in the observation group than in the control group（P〈0.05）.After treatment,the level of ET-1 in the observation group was much lower than that in the control group,while the level of CGRP was much higher than that of the control group（P〈0.05）.The quality of life,scores of somatic function,somatic role,bodily pain,general health status,vitality,social function and mental health in the observation group were all statistically better than those in the control group（P〈0.05）;while the scores of emotional role were not statistically different between both groups（P〈0.05）.During the treat-ment,the incidence of allergy in the control group and the observation group was 6.7% and 5.0% res
出处
《中国现代医学杂志》
CAS
北大核心
2015年第30期57-61,共5页
China Journal of Modern Medicine
关键词
益气健脑方
针刺
缺血性脑卒中恢复期
并发症
生活质量
Yiqi Jiannao Decoction
acupuncture
recovery stage of ischemic apoplexy
complication
life quality
