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Ki-67增殖指数与脑膜瘤病理分级及预后的相关性 被引量:7

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摘要 目的 探讨Ki-67增殖指数与不同级别和亚型脑膜瘤及其复发的相关性。方法 依据WHO(2014)中枢神经系统诊断标准从607例脑膜瘤中随机选取Ⅰ级脑膜瘤60例、Ⅱ级脑膜瘤20例、Ⅲ级脑膜瘤18例、复发性脑膜瘤20例及侵犯脑组织脑膜瘤13例行Ki-67免疫组化检测。607例中女性多发,发病年龄2~75岁,中位年龄53岁,其中7例年龄小于18岁。607例样本中Ⅰ、Ⅱ和Ⅲ级脑膜瘤分别为551、38和18例。结果 Ki-67表达水平与脑膜瘤级别呈正相关(P〈0.05);同级别复发和未复发、Ⅱ级脑膜瘤侵犯脑组织和未侵犯脑组织脑膜瘤中,Ki-67表达差异有统计学意义(P〈0.05)。结论 Ki-67表达水平与脑膜瘤级别呈正相关,复发性、侵犯脑组织脑膜瘤的Ki-67增殖指数较同级别脑膜瘤增高。
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2015年第11期1281-1283,共3页 Chinese Journal of Clinical and Experimental Pathology
基金 陕西省国际科技合作项目(2014KW21-01)
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