摘要
目的:分析临床铜绿假单胞菌感染的药敏变化,比较ICU与非ICU铜绿假单胞菌的耐药性,为临床合理使用抗菌药物提供参考。方法:选取2013年1月—2014年12月间临床各类标本中分离的544株铜绿假单胞菌(剔除同一患者7 d内重复分离的菌株),其中ICU 237株与非ICU 307株;铜绿假单胞菌的培养鉴定严格按照原卫生部制定的《临床微生物检验操作规范》要求;药敏试验采用K-B纸片法,用SPSS 19.0版统计学软件分析临床分离细菌的药敏试验结果。结果:ICU和非ICU铜绿假单胞菌对环丙沙星、亚胺培南、左氧氟沙星、美洛培南和哌拉西林的耐药率分别为46.99%,67.93%,59.49%,56.12%,42.62%和14.33%,20.20%,25.08%,8.79%,22.15%;ICU铜绿假单胞菌感染的耐药率明显高于非ICU(P<0.05)。结论:ICU铜绿假单胞菌的耐药率高于ICU,在临床选用抗菌药物治疗铜绿假单胞菌感染时应根据当地细菌耐药特点,合理选用抗菌药物,以防止多重耐药铜绿假单胞菌甚至是泛耐药菌株的传播与感染。
Objective： To analyze the change of drug susceptibility of the clinical Pseudomonas aeruginosa isolates causing infections and to compare the drug resistance between the ICU and non-lCU Pseudomonas aeruginosu isolates, so as to provide a reference for reasonable clinical use of antibiotics. Methods： A total of 544 strains of Pseudomonas aeruginosa were isolated from the clinical specimens from January 2013 to December 2014 （Eliminatingthe same patients within 7 days of repeated isolates）, including 237 ICU strains and 307 non-ICU strains, then the culture and identification of Pseudomonas aeruginosa isolates were carried out strictly in accordance with the national guide to clinical laboratory procedures issued by the original Ministry of Public Health,the drug susceptibility testing was performed by means of K-B disk methods, and the results of the drug susceptibility testing for the clinical isolates were statistically analyzed with the use of SPSS 19.0 software. Results：The drug resistance rates of the ICU and non-ICU Pseudomonas aeruginosa strains to cciprofloxacin, imipenem, levofloxacin tablets, meropenem and piperacillin were 46.99%, 67.93%, 59.49%, 56.12% and 42.62% respectively which were significantly higher than 14.33%, 20.20%, 25.08%, 8.79% and 22.15% of the non-ICU strains （P〈 0.05）. Conclusion：The drug resistance rate of the ICU P.aeruginosa isolates is significantly higher than that of the non-ICU strains, and it is necessary for the hospital to reasonably use antibiotics on the basis of the characteristics of local Pseudomonas aeruginosa isolates causing infections so as to prevent the spread and infections of the multiple-drug resistant Pseudomonas aeruginosa, even the pan-drug resistant strains.
出处
《抗感染药学》
2015年第5期693-696,共4页
Anti-infection Pharmacy
