摘要
目的观察1型糖尿病患者L-高精氨酸(L-HArg)和不对称性二甲基精氨酸(ADMA)水平变化,探讨其与心血管疾病的关系。方法选取2010—2012年宝鸡市人民医院收治的1型糖尿病患者89例作为观察组,另选取同期体检健康者90例作为对照组。比较两组受试者入院时血清L-HArg、ADMA、L-精氨酸(L-Arg)水平。随访2年,将观察组患者按心血管事件发生情况分为严重心血管事件组(n=16)、一般心血管事件组(n=18)和无心血管事件组(n=55)3个亚组,比较3个亚组患者血清L-HArg、ADMA、L-Arg及超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白介素6(IL-6)水平,并分析血清L-HArg、ADMA水平与心血管事件发生率、hsCRP、TNF-α、IL-6的相关性。结果两组受试者血清L-Arg水平比较,差异无统计学意义(P>0.05);观察组患者血清L-HArg水平低于对照组,血清ADMA水平高于对照组(P<0.05)。3亚组患者血清L-Arg水平比较,差异无统计学意义(P>0.05);一般心血管事件组患者血清L-HArg水平低于无心血管事件组,血清ADMA及hs-CRP、TNF-α、IL-6水平高于无心血管事件组(P<0.05);严重心血管事件组患者血清L-HArg水平低于一般心血管事件组和无心血管事件组,血清ADMA及hs-CRP、TNF-α、IL-6水平高于一般心血管事件组和无心血管事件组(P<0.05)。Pearson相关性分析结果显示,血清L-HArg水平与心血管事件发生率、血清hs-CRP、TNF-α、IL-6水平呈负相关(r值分别为-0.458、-0.389、-0.235、-0.224,P值分别为0.000、0.005、0.023、0.033),血清ADAM水平与心血管事件发生率、血清hs-CRP、TNF-α、IL-6水平呈正相关(r值分别为0.421、0.302、0.265、0.228,P值分别为0.001、0.003、0.031、0.032)。结论 1型糖尿病患者血清L-HArg水平较低,其与患者心血管事件发生率呈负相关;1型糖尿病患者血清ADMA水平较高,其与患者心血管事件发生率呈正相关;二者均可通过影响一氧化氮的合成而引发血管内皮功能紊�
Objective To observe the changes of serum levels of L - homoarginine and asymmetric dimethylarginine, to investigate their correlations with cardiovascular disease in patients with type 1 diabetes mellitus. Methods A total of 89 patients with type 1 diabetes mellitus were selected as observation group in People＇s Hospital of Baoji from 2010 to 2012, and a total of 90 healthy people were selected as control group at the same time; according to the incidence of cardiovascular events during the 2 - year fellow - up, patients of observation group were divided into three subgroups： A group （with severe cardiovascular events, n = 16）, B group （with general cardiovascular events, n = 18）, C group （without eardiovaseular events, n = 55） . Serum levels of L -homoarginine, asymmetric dimethylarginine and L - arginine at admission were compared between observation group and control group, while serum levels of L - homoarginine, asymmetric dimethylarginine, L - arginine, hs- CRP, TNF-α, IL- 6 were compared among A group, B group and C group, correlations between serum L - homoarginine, asymmetric dimethylarginine levels and incidence of cardiovascular events, sermn levels of hs - CRP, TNF - α and IL -6 were analyzed. Results No statistically significant differences of L - arginine was found between control group and observation group （P 〉0.05 ）, while serum L- homoarginine level of observation group was statistically significantly lower than that of control group, serum asymmetric dimethylarginine level of observation group was statistically significantly higher than that of control group （ P 〈 0. 05 ） . No statistically significant differences of L - arginine was found among A group, B group and C group （P 〉 0. 05 ）, while serum L - homoarginine level of B group was statistically significantly lower than that of C group, serum levels of asymmetric dimethylarginine, hs - CRP, TNF - α and IL -6 of B group were statistically significantly higher than those of C group （ P 〈 0. 05 ） ; s
出处
《实用心脑肺血管病杂志》
2015年第9期18-21,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
