摘要
目的:探讨阻塞性睡眠呼吸暂停(OSA)对急性ST段抬高型心肌梗死(STEMI)直接经皮冠状动脉介入(PCI)术后心功能恢复情况的影响。方法:收集STEMI行直接PCI患者242例,其中合并OSA 71例(重度OSA 20例),分析术后心电图、心肌酶学峰值、左心指数(CI)、射血分数(EF)及1个月后6分钟步行试验结果。结果:OSA组术后30min心电图ST段回落<50%46例(64.79%),高于对照组(P<0.05);CI、EF均低于对照组(P<0.05);6分钟步行试验表明重度心功能不全(<150 m)14例(19.72%),高于对照组(P<0.05)。重度OSA组CI、EF低于轻中度OSA组。结论:OSA加重STEMI患者直接PCI术后的心肌损害、并影响心功能恢复;其影响情况可能随睡眠呼吸暂停严重程度而加重。
Objective：To explore the impact of obstructive sleep apnea on heart function in patients with STsegment myocardial infarction after emergency PCI.Method：We collected 242 patients with ST-segment myocardial infarction after emergency PCI.Of 242 patients,71had obstructive sleep apnea（OSA）,and 20 patients with serious OSA.Then we analyzed these group data of electrocardiogram after 30 min of PCI,peak value of myocardial enzyme,cardiac index（CI）,ejection fraction and 6minutes walk test after 1 month of PCI.Result：The incidence of ST-segment resolution（STR）50% after 30 min of PCI was higher in OSA patients than in control patients（64.79% vs 51.46%,P〈0.05）.The level of CI was lower in OSA patients than in control patients.Six minutes walk test show that the incidence of Severe heart failure（150m）higher in OSA patients than in control patients（19.72% vs 9.4%,P〈0.05）.The level of CI was lower in serious OSA patients than in mild to moderate OSA patients.Conclusion：Obstructive sleep apnea may impair myocardial tissue and impact the heart function in patients with ST-segment myocardial infarction after emergency PCI.The more serious obstructive sleep apnea is,the deeper degree of influence is.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2015年第11期1175-1178,共4页
Journal of Clinical Cardiology
基金
福建省龙岩市科技局基金项目(No:2012LY73)
关键词
阻塞性睡眠呼吸暂停
经皮冠状动脉介入
心功能
obstructive sleep apnea
percutaneous coronary intervention
heart function
