期刊文献+

温度调节基因开关调控大肠杆菌发酵

Fermentation in recombinant Escherichia coli with thermo-regulated genetic switch
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摘要 微生物作为细胞工厂,已被应用于许多同源及异源代谢产物的生产,包括发酵型产物(氨基酸、有机酸、有机醇)以及众多次级代谢产物的生产[1-4]。然而,其中多数代谢产物的过量合成会对细胞造成伤害,抑制细胞的生长或者使代谢流失衡[5-6]。
作者 邱并生
出处 《微生物学通报》 CAS CSCD 北大核心 2015年第11期2270-2271,共2页 Microbiology China
关键词 L-丙氨酸 基因开关 大肠杆菌 发酵 代谢工程 L-alanine, Genetic switch, Escherichia coli, Fermentation, Metabolic engineering
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参考文献10

  • 1Kern A, Tilley E, Hunter IS, et al. Engineering primary metabolic pathways of industrial micro-organisms[J]. Journal of Biotechnology, 2007,129(1): 6-29. 被引量:1
  • 2Kramer R. Genetic and physiological approaches for the production of amino acids[J]. Journal of Biotechnology, 1996,45(1): 1-21. 被引量:1
  • 3Mijts BN, Schmidt-Dannert C. Engineering of secondary metabolite pathways[J]. Current Opinion in Biotechnology, 2003, 14(6): 597-602. 被引量:1
  • 4Jones BB, Chan H, Rothstein S, et al. RNA polymerase binding sites in ",plac5 DNA[J]. Proceedings of the National Academy of Sciences of Sciences of the United States of America, 1977,74(11): 4914-4918. 被引量:1
  • 5Bunch PK, Mat-Jan F, Lee N, et al. The IdhA gene encoding the fermentative lactate dehydrogenase of Escherichia coli[J]. Microbiology, 1997, 143(1): 187-195. 被引量:1
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  • 8Smith GM, Lee SA, Reilly KC, et al. Fed-batch two-phase production of alanine by a metabolically engineered Escherichia coli[J]. Biotechnology Letters, 2006, 28(20): 1695-1700. 被引量:1
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  • 10周丽,邓璨,崔文璟,刘中美,周哲敏.温度调节基因开关调控大肠杆菌发酵合成L-丙氨酸[J].微生物学通报,2015,42(11):2272-2281. 被引量:15

二级参考文献20

  • 1杨扬,秦强,郭伟忠.苯基异硫氰酸酯衍生氨基酸的高效液相色谱分析[J].色谱,1994,12(4):295-296. 被引量:18
  • 2Kern A, Tilley E, Hunter IS, et al. Engineering primary metabolic pathways of industrial micro-organisms[J]. Journal of Biotechnology, 2007,129(1): 6-29. 被引量:1
  • 3Kramer R. Genetic and physiological approaches for the production of amino acids[J]. Journal of Biotechnology, 1996, 45(1): 1-21. 被引量:1
  • 4Mijts BN, Schmidt-Dannert C. Engineering of secondary metabolite pathways[J]. Current Opinion in Biotechnology, 2003, 14(6): 597-602. 被引量:1
  • 5Jones BB, Chan H, Rothstein S, et al. RNA polymerase binding sites in Aplac5 DNA[J]. Proceedings of the National Academy of Sciences of Sciences of the United States of America, 1977, 74(11): 4914-4918. 被引量:1
  • 6Bunch PK, Mat-Jan F, Lee N, et al. The IdhA gene encoding the fermentative lactate dehydrogenase of Escherichia coliC J]. Microbiology, 1997, 143(1): 187-195. 被引量:1
  • 7Zhou L, Niu DD, Tian KM, et al. Genetically switched D-Iactate production in Escherichia coli[J]. Metabolic Engineering, 2012, 14(5): 560-568. 被引量:1
  • 8Zhou L, Zuo ZR, Chen XZ, et al. Evaluation of genetic manipulation strategies on D-Iactate production by Escherichia coli[J]. Current Microbiology, 2011, 62(3): 981-989. 被引量:1
  • 9Love CA, Lilley PE, Dixon NE. Stable high-copy-number bacteriophage[lambda] promoter vectors for overproduction of proteins in Escherichia coli[J]. Gene, 1996, 176(1/2): 49-53. 被引量:1
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