摘要
目的研究参麦注射液治疗老年直立性低血压患者的疗效。方法将老年直立性低血压患者97例随机分为2组,治疗组49例静脉滴注参麦注射液100 m L,对照组48例静脉滴注葡萄糖水(5%葡萄糖注射液)100 m L,均每天1次,疗程14 d,比较两组患者用药前后临床症状评分、血压差值变化及血小板最大聚集率、血浆P选择素水平。结果与对照组比较,治疗组患者临床症状评分显著降低(P<0.05),立、卧位血压差值缩小(P<0.05),血小板最大聚集率、血浆P选择素水平降低(P<0.05);治疗组患者用药后临床症状评分较用药前显著降低(P<0.05),立、卧位血压差值显著缩小(P<0.0 5),血小板最大聚集率、血浆P选择素水平显著下降(P<0.05)。结论参麦注射液可缩小老年直立性低血压患者立、卧位血压差值,抑制血小板活性,从而改善临床症状。
Objective To investigate the effect of Shenmai injection in treating elderly with orthostatic hypotension. Methods The total of 97 cases of patients with orthostatic hypotension were randomly divided into 2 groups, which was injected intravenously with 100 mL Shenmai injection once daily as the treatment group, with 100 mL glucose as the control.The treatment lasted 14 days. The clinical symptom score, the difference of blood pressure, the P-selectin, and the platelet maximum aggregation were measured. Results Compared with the control, Shenmai injection significantly reduced the clinical symptom scores of patients （P〈0.05）, lowered the difference of blood pressure for upright and supine significantly （P〈0.05）, decreased the platelet maximum aggregation and P-selectin remarkably （P〈0.05）. Conclusion Shenmai injection significantly reduces the difference of blood pressure for upright and supine of the elderly with orthostatic hypotension, and inhibits the activities of platelets, thus improves the clinical symptoms.
出处
《医药导报》
CAS
2015年第11期1472-1475,共4页
Herald of Medicine
基金
广东省中医药局科研课题(20122191)
关键词
参麦注射液
低血压
直立性
老年
血压
体位
Shenmai injection
Hypotension,orthostatic,elderly
Blood pressure
Position
