摘要
目的新建身高预测方法，并将之用于特发性中枢性性早熟（ICPP）女孩促性腺激素释放激素类似物（GnRHa）治疗过程中的身高预测，以其达到的终身高进行初步验证，了解该方法的应用价值及可靠性。方法（1）新建方法：根据Bayley—Pinneau法骨龄与达到终身高的百分率相关的原理，结合中国2005年九省／市儿童体格发育调查数据，建立身高预测公式：预测成人身高=实测身高／当前骨龄身高占成人身高的百分比。（2）应用新建方法LjBayley—Pinneau法，分别对17例经GnRHa治疗的性早熟患儿进行治疗前后的成人身高预测，并与其已达到的实际终身高进行比较。结果17例ICPP患儿的实际终身高为（159．81±4．95）cm。治疗前、治疗1年后、治疗2年后、治疗3年后新建方法的预涣0成人身高分别为（156．53±3．63）cm、（157．71±3．62）cm、（158．60±3．50）cm、（161．46±4．50）cm，Bayley．Pinneau法的预测成人身高分别为（161．56±3．77）cm、（161．68±3．44）cm、（162．04±4．42）cm、（163．13±2．36）cm。新建方法预测成人身高、Bayley—Pinneau法的预测成人身高与实际终身高平均差值分别为-1．96cm、1．48cm，95％可信区间分别为（-3．82～-0．11）cm、（-1．60～4．55）cm。以Bayley—Pinneau法预测患儿治疗前、后成人身高差异无统计学意义，提示GnRHa治疗未改善患儿的预测成人身高；应用新建方法进行成人身高预测，治疗后较治疗前预测值有所增加，且随治疗时间的延长，预测成人身高改善明显。治疗结束时，预测成人身高与终身高差异无统计学意义。终身高与治疗结束时预测成人身高的相关系数为0．93，回归趋势线与基线基本平行。结论新建方法可较好地预测国内GnRHa治疗的ICPP女孩的终身高。
Objective To develop a new method for predicting adult height （PAH） based on the theory of Bayley-Pinneau and to evaluate the feasibility of this method in predicting adult height of girls with idiopathic central precocious puberty （ICPP） who were treated with gonadotropin releasing hormone agonist （GnRHa）. Method （ 1 ） The new method for PAH, i.c. PAH = Height/percentage of adult height for bone age, was established according to the theory of Bayley-Pinneau and the data from the national growth survey of children in the nine cities of China in the year 2005. （2） Data from seventeen female patients with ICPP received GnRHa treatment and achieved final adult height （FAH） were collected. Before and during the treatment, PAH was calculated by the method of Bayley-Pinneau and the new method. Result The mean FAH （cm） of the 17 patients with ICPP was 159. 81 ± 4. 95. The PAH （ cm）, before and after treatment for 1, 2 and 3 years, were 156. 53 ±3. 63, 157.71± 3.62, 158. 60 ± 3.50, 161.46 ± 4. 50 and 161.56 ± 3.77, 161.68 ±3.44, 162.04±4. 42, 163.13 ±2. 36 respectively by using the new method （PAH-D） and Bayley-Pinneau method（PAH-BP）. The mean value of （ PAH-D - FAH） and （ PAH-BP - FAH） were -1.96cmand 1.48 cm. However, the 95% confidence interval was （ -3.82 cm to -0.11 cm）, （ - 1.60 cm to 4. 55 cm） for （ PAH-D - FAH） and （ PAH-BP - FAH）. There was no significant difference between the values obtained before and after treatment in terms of PAH by use of Bayley-Pinneau method. By the new method, however, the resuhs showed that the PAH increased and improved further with prolonged treatment periods. And at the end of treatment, there was no significant difference between PAH and FAH. The correlation coefficient was 0. 93. Regression analysis showed that the trend line was in parallel with baseline data. Conclusion The new method we established could predict better the final heights of girls with CPP who were treated with GnRHa.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2015年第11期840-844,共5页
Chinese Journal of Pediatrics
基金
卫生部临床学科重点建设项目
“十二五”国家科技支撑计划项目（2012BA109B04）
关键词
预测成人身高
中枢性性早熟
Predicted adult height
Central precocious puberty
