摘要
长链非编码RNA(long non-coding RNA,lncRNA)起初被认为是基因组转录的"噪音"或"转录垃圾"。随着研究的深入和测序技术的发展,越来越多的lncRNA被发现,虽然lncRNA不编码蛋白质,但可在多层面、通过多途径调控基因表达,从而影响疾病的发生、发展,尤其与肿瘤的发生、发展密不可分。膀胱癌是泌尿系统最常见的恶性肿瘤,其高发病率和高复发率一直是泌尿外科医生和膀胱癌患者的困扰,且病因尚不十分明确。lncRNA与膀胱癌的关系也逐渐受到关注,本文以几个lncRNA(H19,UCA1/UCA1a,MALAT-1,HOTAIR,ncRAN,MEG3)为代表,阐述了lncRNA与膀胱癌的发生、发展与复发的密切关系,并预测通过lncRNA诊断和治疗膀胱癌的临床前景。
Long non - coding RNAs （ lncRNAs ） were initially considered as transcriptional ＂noise＂ or ＂junk＂. With in -depth researches,it was found that lncRNAs could regulate gene expression at multiple levels and pathways and thus affect the occurrence and progression of various diseases including some malignant tumors although no protein products are encoded. Bladder cancer is the most common malignant tumor of urinary system. Its pathogenesis involvesthe effects of various lncRNAs. Taking several lncRNAs （ H19, UCA1/UCAla, MALAT - 1, HOTAIR, ncRAN, MEG3 ） as examples, this review elaborates on the effects of lncRNAs on bladder cancer and predicts the applications of relat- ed lncRNAs in diagnosing and treating bladder cancer.
出处
《现代肿瘤医学》
CAS
2015年第24期3685-3690,共6页
Journal of Modern Oncology
基金
国家自然基金(编号:81460450)
海南省自然基金资助项目(编号:813256)
海南省重点项目(编号:ZDXM2014076)
海口市重点资助项目(编号:2012-073)
