摘要
目的：探讨丹红注射液对短暂性脑缺血发作（transient ischemic attack, TIA）患者血流动力学及血清胱抑素 C（cystatin C, Cys-c）和血清同型半胱氨酸（homocysteine, Hcy）表达的影响。方法将符合入选标准的 TIA 患者80例，按随机数字表法分为2组各40例，对照组予常规西医治疗，观察组在对照组基础上静脉滴注丹红注射液，共治疗14 d。观察治疗前后 TIA 患者脑血管血流动力学变化及血清 Cys-c、Hcy 的表达，评价临床疗效。结果治疗后，观察组血流平均速度[（20.07±4.28）cm/s 比（16.17±2.46）cm/s， t＝5.230]、平均血流量[（11.14±2.24）ml/s 比（9.54±1.65）ml/s，t＝3.637]均较对照组升高（P＜0.05），脑血管阻力[（1602.4±98.3）kPa/s·m-1比（1738.5±104.3）kPa/s·m-1，t＝6.024]较对照组降低（P＜0.05）；观察组血清Cys-c[（0.48±0.11）mg/L 比（0.71±0.14）mg/L，t＝8.170]、Hcy[（17.45±3.26）μmol/L 比（23.62±4.12）μmol/L， t＝7.428]均较对照组降低（P＜0.01）。观察组 TIA 复发率和脑梗死发生率分别为7.5%（3/40）、5.0%（2/40），对照组分别为22.5%（9/40）、15.0%（6/40），2组复发率和脑梗死发生率比较，差异均有统计学意义（χ2值分别为2.451、2.630，P＜0.05）。结论丹红注射液可降低 TIA 患者血清 Cys-c、Hcy 表达，降低复发与脑梗死的发生率。
Objective To detect the effect of Danhong injection on cerebral vascular hemodynamic parameters, Cys-c and Hcy in patients with transient cerebral ischemia（TIA）, and analyze its clinical effect. Methods 80 TIA patients were selected. The patients were divided into a control group and a Danhong injection observation group with 40 cases each group. The control group was given conventional treatment, and the observation group was given conventional treatment and Danhong injection. The treatment course was 14 d. The hemodynamic parameters, Cys-c and Hcy expresssion were observed. Clinical effect was analyzed. Results After treatment, average blood flow speed （20.07 ± 4.28 cm/s vs. 16.17 ± 2.46 cm/s, t=5.230）, average blood flow （11.14 ± 2.24 ml/s vs. 9.54 ± 1.65 ml/s, t=3.637）, and cerebral vascular resistance （1 602.4 ± 98.3 kPa/s·m-1 vs. 1 738.5 ± 104.3 kPa/s·m-1, t=6.024） was significantly improved in the observation group than those in the control group （P〈0.05）. Cys-c （0.48 ± 0.11 mg/L vs. 0.71 ± 0.14 mg/L, t=8.170） and Hcy （17.45 ± 3.26 μmol/L vs. 23.62 ± 4.12 μmol/L, t=7.428） were significantly decreased in the observation group than those in the control group （P〈0.05）. The recurrence rate of TIA and cerebral infarction were 7.5% and 5% in observation group, which were significantly lower than that of 22.5% and 15% in control group （χ2=2.451, P〈0.05;χ2=2.630, P〈0.05）.Conclusion Danhong injection can reduce the expression of Cys-c and Hcy and recurrence rate of TIA and cerebral infarction.
出处
《国际中医中药杂志》
2015年第11期984-986,共3页
International Journal of Traditional Chinese Medicine
