摘要
目的探讨阿托伐他汀联合阿司匹林治疗急性脑梗死(ACI)的效果。方法抽取2018年1月至2021年12月河南中医药大学第一附属医院收治的ACI患者100例,采用双色球法分为对照组与观察组,每组50例。对照组采用阿司匹林治疗,观察组采用阿托伐他汀治疗。比较两组的治疗效果及治疗前后美国国立卫生院神经功能缺损评分量表(NIHSS)评分、炎症因子及血脂指标。结果观察组总有效率(96.00%,48/50)高于对照组(78.00%,39/50),P<0.05。治疗前,两组NIHSS评分、炎症因子、血脂指标比较差异未见统计学意义(P>0.05);治疗后,观察组NIHSS评分、炎症因子水平及总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平均低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P<0.05)。结论阿司匹林联合阿托伐他汀治疗ACI,可提高治疗效果,更好改善患者的血脂指标与炎症因子水平及神经功能缺损症状。
Objective To investigate the effect of atorvastatin combined with aspirin on acute cerebral infarction(ACI).Methods A total of 100 cases of ACI patients treated in the First Affiliated Hospital of Henan University of Chinese Medicine from January 2018 to December 2021 were sampled,and they were divided into control group and observation group by the two-color ball method,with 50 cases in each group.The control group was treated with aspirin,and the observation group was treated with atorvastatin combined with aspirin.The curative effects,preoperative and postoperative National Institutes of Health Stroke Scale(NIHSS)score,inflammatory factors and blood lipid indexes were compared between the two groups.Results The total effective rate of the observation group(96.00%,48/50)was higher than that of the control group(78.00%,39/50),P<0.05.Before treatment,there was no significant difference in NIHSS score,inflammatory factors and blood lipid indexes between the two groups(P>0.05).After treatment,NIHSS score,levels of inflammatory factors,total cholesterol,triglyceride and low-density lipoprotein cholesterol in the observation group were lower than those in the control group,while level of high-density lipoprotein cholesterol was higher than that in the control group(P<0.05).Conclusions Aspirin combined with atorvastatin in the treatment of ACI patients can improve the curative effect,levels of blood lipid indexes,levels of inflammatory factors and the symptoms of neurological deficit.
作者
林芳芳
Lin Fangfang(Department of Emergency,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《中国实用医刊》
2022年第23期93-96,共4页
Chinese Journal of Practical Medicine
关键词
脑梗死
阿托伐他汀
生活质量
血脂指标
炎症因子
Cerebral infarction
Atorvastatin
Quality of life
Blood lipid indexes
Inflammatory factors
