摘要
目的:探讨兰索拉唑与生长抑素联合治疗急性上消化道出血的临床疗效与安全性.方法:选取2011-01/2013-12余姚市第二人民医院急性上消化道出血患者86例作为此次研究对象,将其按照随机数字表法分为联合组与对照组,均43例.对照组给予常规兰索拉唑治疗,联合组给予兰索拉唑与生长抑素治疗,观察两组患者的临床治疗总有效率、成功止血时间、接受治疗时间和不良反应.结果:联合组的有效率高于对照组总有效率(93.0%vs 72.1%)(P<0.05).联合组成功止血时间和接受治疗时间均短于对照组(25.7 h±8.7 h vs 44.7 h±10.3 h,6.7 d±1.1 d vs 11.8 d±1.7 d)(P<0.05).联合组与对照组治疗过程中均未见有任何的不良反应.结论:临床中对于急性上消化道出血患者给予兰索拉唑与生长抑素联合治疗效果显著,明显的缩短成功止血时间和接受治疗时间,且不良反应少,治疗安全性高,值得临床中应用与推广.
AIM：To investigate the clinical effects of lansoprazole combined with somatostatin in the treatment of acute upper gastrointestinal bleeding.METHODS：Eighty-six patients with acute upper gastrointestinal hemorrhage treated from January 2011 to December 2013 in Yuyao Second People＇s Hospital were randomly divided into a combination treatment group and a control group.The control group was given lansoprazole alone,and the combination group was given lansoprazole combined with somatostatin.The total response rate,time to successful hemostasis,treatment duration and adverse reactions were compared between the two groups.RESULTS：The total response rate was significantly higher in the combination group than in the control group（93.0%vs 72.9%,P〈0.05）.The time to successful hemostasis and treatment duration were significantly shorter in the combination group than in the control group（25.7 h ± 8.7 h vs 44.7 h ± 10.3 h,6.7 d ±1.1 d vs 11.8 d ± 1.7 d,P〈0.05）.There was no adverse reaction in either group.CONCLUSION：Lansoprazole combined with somatostatin in the treatment of acute upper gastrointestinal bleeding is associated with higher response rate,shorter bleeding time and treatment duration,and fewer adverse reactions compared with lansoprazole alone.
出处
《世界华人消化杂志》
CAS
2015年第29期4756-4759,共4页
World Chinese Journal of Digestology
关键词
急性
上消化道出血
兰索拉唑
生长抑素
临床疗效
Acute
Upper gastrointestinal bleeding
Lansoprazole
Somatostatin
Clinical efficacy
