摘要
目的探讨质子泵抑制剂雷贝拉唑治疗上消化道出血的临床效果。方法选取2012年10月～2013年10月本院收治的上消化道出血患者160例，将其按照随机数字表法分为观察组和对照组各80例。观察组采用质子泵抑制剂雷贝拉唑进行治疗，20mg口服，2次／d，对照组采用H2受体拮抗剂西咪替丁进行治疗，400mg静脉滴注。2次／d，两组均治疗3d。比较两组的临床疗效、再出血率及不良反应情况。结果观察组的总有效率为95．00％，显著高于对照组的81．25％（P〈0.05）；观察组的再出血率为5．00％，显著低于对照组的27．50％（P〈0．05）。两组的不良反应发生率差异无统计学意义（P〉0.05）。结论在同等治疗条件下，雷贝拉唑治疗上消化道出血的临床效果优于西咪替丁。可明显抑制再出血的发生，无严重不良反应，值得临床推广应用。
Objective To investigate the clinical effect of proton pump inhibitor of rabeprazole in the treatment of up- per gastrointestinal bleeding. Methods 160 patients with upper gastrointestinal bleeding in our hospital from October 2012 to October 2013 were selected and were randomly divided into the observation group （n=80） and the control group （n=80） according the random number table method, the proton pump inhibitor of oral rabeprazole 20 mg was used in the observation group,2 times a day, H2 receptor antagonist of cimetidine 400 mg for intravenous infusion was used in the control group, 2 times a day,both groups were treated for 3 days.The clinical efficacy,rebleeding rate and adverse reactions of the two groups was compared. Results The total effective rate of the observation group （95.00%） was sig- nificantly higher than that of the control group （81.25%）（P〈0.05）;rebleeding rate of the observation group （5.00%） was significantly lower than that of the control group （27.50%） （P〈0.05）; The incidence of adverse reactions of the two groups had no statistical difference （P〉0.05）. Conclusion Under the same treatment conditions,the clinical effect of rabeprazole in the treatment of gastrointestinal bleeding is better than that of cimetidine and it can inhibit the occurrence of rebleeding having no serious adverse reactions,and it is worthy of clinical promotion and application.
出处
《中国当代医药》
2014年第4期79-80,83,共3页
China Modern Medicine
关键词
上消化道出血
雷贝拉唑
西咪替丁
Upper gastrointestinal bleeding
Rabeprazole
Cimetidine
