摘要
目的了解阿尔兹海默病(AD)患者生活质量及其影响因素,为AD的临床治疗工作提供科学依据。方法采用以医院为基础病例对照研究方法对华中科技大学同济医学院附属梨园医院精神科2013年1月—2014年12月收治的378例≥60岁AD患者及同期在该医院进行健康体检的400名≥60岁健康体检者进行问卷调查,评价其生活质量,并采用多元线性逐步回归模型分析AD患者生活质量相关影响因素。结果病例组AD患者阿尔兹海默病生活质量量表(QOL-AD)总分为(31.43±4.21)分,低于对照组健康体检者的(44.56±4.18)分,差异有统计学意义(t=39.675,P<0.001);病例组AD患者简易精神状态检查量表(MMSE)和日常生活功能量表(ADL)得分分别为(15.82±7.65)和(51.71±13.28)分,均低于对照组健康体检者的(21.83±6.56)和(65.68±14.18)分(均P<0.05);病例组AD患者神经精神调查量表(NPI)和老年抑郁量表(GDS)得分分别为(31.14±7.27)和(19.24±6.56)分,均高于对照组健康体检者的(21.06±8.58)和(14.53±6.18)分(均P<0.05);相关分析结果显示,MMSE量表得分与QOL-AD量表总分呈正相关(r=0.342,P=0.016),GDS量表得分与QOL-AD量表总分呈负相关(r=-0.584,P<0.001);多元线性逐步回归分析结果显示,年龄越大、照顾者关系越不亲密、与照顾者同住、痴呆程度越重、GDS量表得分越高,AD患者生活质量越差。结论 AD患者生活质量较差,年龄、照顾者、居住情况、痴呆程度和GDS量表得分是AD患者生活质量的主要影响因素。
Objective To study the quality of life （QOL） and its influencing factors among the elderly with Alzheimer＇s disease（AD） and to provide bases for clinical treatment of AD. Methods A hospital-based case-control study was conducted from January 2013 to December 2013 in Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, with 378 AD patients aged 60 years and over and 400 healthy elderly of same ages visiting the hospital for physical examination during the same period. The QOL of the participants was evaluated with several scales and multivariate linear stepwise regression model was used to analyze related factors of QOL. Results Compared to the controls, the AD patients had significantly lower total scores for Quality of Life-Alzermer＇s Disease （QOL-AD） （ 31.43±4. 21 vs. 44. 56 ± 4. 18 ; t = 39. 675, P 〈 0. 001 ）, Mini-Mental State Examination （MMSE） （ 15.82 ±7. 65 vs. 21.83 ± 6. 56, P 〈 0. 05 ）, and Activity of Dally Life （ADL） （51.71 ± 13.28 vs. 65.68 ±14. 18, P 〈 0. 05 ） but significantly higher scores for Neuropsychiatric Inventory （NPI） （ 31.14 ± 7.27 vs. 21.06 ± 8. 58 ） and Geriatric Depres- sion Scale（GDS） （ 19. 24 ± 6. 56 vs. 14. 53 ± 6. 18 ） （ all P 〈 0. 05 ）. Correlation analysis showed that MMSE score and QOL-AD total score were positively correlated （ r = 0. 342, P = 0. 016 ） and GDS score and QOL-AD total score were reveresely correlated（ r = - 0. 584, P 〈 0. 001 ）. Mmultivariate linear regression analyses showed that the AD patients at older age, having less intimate relationship with the caregiver, living with a caregiver, having severe dementia, and with high GDS score had poor QOL. Conclusion Elderly AD patients had poor QOL and age, relationship with caregiver, living condition, severity of dementia, and GDS score are main impact factors of QOL in the elderly AD patients.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2015年第11期1481-1485,共5页
Chinese Journal of Public Health
