摘要
超顺磁性氧化铁纳米粒子(SPION)正作为一种新型纳米材料被广泛研究。SPION具有超顺磁性、靶向性、良好的生物相容性、易观察性、可塑性等特性,不仅可以作为磁共振成像(MRI)造影剂,用于临床癌症的早期诊断;还可以作为磁靶向药物载体,将药物选择性地输送至靶向病变部位,提高药物的生物利用度,成为多种药物尤其是抗癌类药物的靶向载体。SPION的研究和应用已得到国内外研究者的高度关注。本文通过查阅大量相关SPION的国内外文献,对SPION在MRI和靶向药物传递的应用研究进展做一综述。
Superparamagnetic iron oxide nanoparticles（SPION）as a new type of nano-materials have been widely studied.Because of their superparamagnetic property,targeting,biocompatibility,easy observability,and plasticity,etc.,SPION have been used not only as magnetic resonance imaging（MRI） contrast agents in the early diagnosis of clinical cancer,but also as targeting drug carrier to selectively deliver the drugs especially anti-cancer drugs to target lesion,and therefore,improve the bioavailability of the drugs. For these reasons,the research on contrast agents and magnetic targeting drug carrier has attracted widespread attention.This paper reviews the research progress of SPION application in MRI and targeted drug delivery through consulting a number of relevant publications.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2015年第5期601-605,共5页
Journal of International Pharmaceutical Research
基金
国家自然科学基金资助项目(81160176)
关键词
超顺磁性氧化铁纳米粒
药物传递系统
磁共振成像
superparamagnetic iron oxide nanoparticles
drug delivery
magnetic resonance imaging
