摘要
目的观察丹参酮ⅡA磺酸钠(STS)对非增生性糖尿病视网膜病变(NPDR)患者视网膜血流动力学的影响。方法予40例NPDR患者在常规治疗的基础上联合STS注射液进行治疗,观察治疗前、后视网膜中央动脉(CRA)、中央静脉(CRV)血流动力学特征,并与健康对照组进行比较。结果 NPDR患者CRA的峰值血流速度(PSV)、舒张末期血流速度(EDV)、平均血流速度(MV)值较正常人降低而搏动指数(PI)、阻力指数(RI)值增高;CRV的PSV、EDV、MV值较正常人增高而PI和RI降低,差异具有统计学意义(P<0.01或P<0.05)。STS治疗可以改善NPDR患者血流动力学指标,治疗后CRA的PSV、EDV、MV值及CRV的RI、PI值较治疗前提高,CRA的RI、PI值及CRV的PSV、EDV、MV值较治疗前降低,差异具有统计学意义(P<0.01或P<0.05)。结论 STS能够改善NPDR患者的视网膜血流动力学状态及视网膜微循环。
Objective To evaluate the effects of sulfotanshinone sodium（ STS） on retinal hemodynamics in nonproliferative diabetic retinopathy（ NPDR） patients. Methods Forty NPDR patients were treated with STS and routine hypoglycemic treatments. The retinal hemodynamics of central retinal artery（ CRA） and central retinal vein（ CRV） were analyzed before and after the treatment and were compared with healthy control group. Results Before treatment,the peak systolic velocity（ PSV）,end diastolic velocity（ EDV） and mean velocity（ MV） of CRA were lower in NPDR patients.The resistance index（ RI） and pulsatility index（ PI） of CRA were higher in NPDR patients. PSV,EDV and MV of CRV were higher and RI and PI were lower in NPDR patients. These differences were significant（ P〈0. 01 and P〈0. 05）.After STS treatment,PSV,EDV and MV of CRA and RI and PI of CRV increased,while RI and PI of CRA and PSV,EDV and MV of CRV decreased. These changes were significant（ P〈0. 01 or P〈0. 05）. Conclusion STS improves retinal hemodynamics and retinal microcirculation in NPDR patients.
出处
《临床眼科杂志》
2015年第5期389-391,共3页
Journal of Clinical Ophthalmology
