摘要
以天然高分子壳聚糖季铵盐和海藻酸钠为壁材,利用气-液剪切原理,在自制的微通道装置中通过复凝聚法形成壳聚糖季铵盐/海藻酸钠微胶囊;同时,原位沉淀法得到的Ca CO3微粒被引入到微胶囊的囊壁中,最终得到壳聚糖季铵盐/海藻酸钠/Ca CO3复合微胶囊.通过三维显微镜和扫描电镜观察复合微胶囊形态和尺寸,并统计复合微胶囊的平均粒径,探索制备复合微胶囊的最佳工艺条件.研究复合微胶囊在不同p H条件下、不同离子强度溶液中的溶胀行为.以水杨酸钠为模型药物,探讨复合微胶囊对药物的包埋作用和释放性能.
Quaternized chitosan/alginate/CaCO3 composite microcapsules were prepared by the coacervation effect of quaternized chitosan and alginate, and in situ precipitation of CaCO3 particles. The composite microcapsules were formed in a microfluidic device based on gas-liquid shearing interaction. The effects of gas flow rate,liquid flow rate,the composition of liquid phase on the size and size distribution of the microcapsules were studied in detail. The morphology and average particle size were characterized and analyzed by 3D video microscopy and SEM. Swelling behavior of the composite microcapsules was studied in aqueous solutions with different pH values and ionic strengths. The encapsulation and release of the microcapsules for model drug were evaluated by ultraviolet spectrophotometry. The optimal conditions to preparing uniform composite microcapsules were the gas rate at 0.7 L/min, the liquid phase rate at 3 mL/h, the alginate concentration at 1.75 wt% ,the quaternized chitosan concentration at 0.8 wt% ,the Na2CO3 concentration at 0. 8 wt% and the CaC12 concentration at 1.75 wt%. The composite microcapsules swelled in alkaline solutions, but scarcely swelled in acidic solutions and natural water. The mieroeapsules presented a more efficient drug release rate in alkaline solutions and at 37℃. When the alginate amount during preparation of the composite microeapsules increased,the relaese rate of the mierocapsules for drug decreased.
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2015年第11期1336-1343,共8页
Acta Polymerica Sinica
基金
国家自然科学基金(基金号50803048)
中央高校基本科研业务专项资金(项目号2013-IV-008)资助项目
