摘要
目的评估CASIASS-1000新型扫频OCT（SS-1000OCT）测量正常人中央角膜厚度（CCT）的重复性，并与A型超声测厚仪结果进行比较，评估2种仪器的一致性。方法前瞻性研究。收集正常受检者62名，均由同一熟练操作者对受检者右眼进行测量，先采用非接触SS-1000OCT，再使用A超重复测量角膜厚度。组内标准系数（ICC）、Bland．Ahman及重复测量方差分析用于评估SS-1000OCT测量CCT的重复性；配对t检验及Bland．Altman用于评估SS．1000OCT与A超的一致性。结果SS．1000OCT重复3次测量CCT的ICC为0．999，第1次与第2欠、第1次与第3次及第2次与第3次的95％一致性区间分别为-2．4～1．8μm、-2．8～2．1μm、-2．8～2．7μm，重复测量方差分析进行两两比较显示差异无统计学意义。SS—1000OCT及A超测量CCT的均值分别为（534．38±24．52）μm和（538．40±25.36）μm，二者95％一致性区间为-12．6～4．5μm。结论SS．1000OCT测量CCT具有很好的重复性，与A型超声测厚仪具有高度的一致性，在临床工作中，可以考虑相互替代。
Objective To assess the repeatability of central corneal thickness （CCT） measurements in healthy eyes by comparing measurements obtained with an SS-1000 swept-source optical coherence tomography （SS-1000 OCT） or by ultrasound pachymetry （USP）; to evaluate the agreement between these two devices. Methods In this prospective study, CCT was recorded after consecutive measurements with SS-1000 OCT and then with USP by a single skilled operator in 62 right eyes of healthy subjects. Intraclass correlation coefficient （ICC）, Bland-Altman plots and repeated-measures analysis of variance （ANOVA） were used to evaluate the repeatability of SS-1000 OCT. Paired t-tests and Bland-Ahman plots were used to evaluate the agreement between the two devices. Results The ICC of the SS-1000 OCT measurements was 0.999. Bland-Ahman plots showed excellent agreement between any two of the three measurements （95% limits of agreement were -2.4 to 1.8μm, -2.8 to 2.1μm, and -2.8 to 2.7 μm）. There was no statistical significance found with repeated-measures ANOVA. The mean values of CCT obtained from the SS-1000 OCT and USP were 534.38±24.52 μm and 538.40±25.36μm, respectively. 95% limits of agreement were -12.6 to 4.5 μm for these two devices. Conclusion The SS-1000 OCT shows excellent repeatability of CCT measurements in healthy eyes. High agreement between CCT measurements suggests that SS-1000 OCT and USP can be used interchangeably in normal subjects.
出处
《中华眼视光学与视觉科学杂志》
CAS
CSCD
2015年第10期604-608,共5页
Chinese Journal Of Optometry Ophthalmology And Visual Science
基金
浙江省医药卫生科技计划项目（2012KYB135）
浙江省教育厅科研项目（Y201223147）
温州市科技局资助项目（Y20130118,Y20120176）
温州市重点创新团队项目（C20120009-04）
关键词
体层摄影术
光学相干
超声检查
A型
中央角膜厚度
可重复性
结果
一致性
Tomography,optical coherence
Ultrasonography,A
Central corneal thickness
Reproducibility of result
Agreement
