摘要
采用GC法测定盐酸美金刚原料药的有关物质。方法：采用DB-17（30 m×0.25 mm×0.25μm）色谱柱,氮气为载气,FID检测器温度300℃,进样口温度为220℃。结果：盐酸美金刚及其已知杂质（杂质A、杂质B、杂质C、杂质E、杂质F）的线性范围分别为5~120μg/m L;平均回收率分别为97.5%、95.3%、96.7%、94.2%和98.4%;结论：本法简便、准确、可靠、适合于盐酸美金刚原料药有关物质测定。
To establish an GC method For quantitative determination of Memantine Hydrochloride. Methods： The analytical column was DB-17（30 m×0.25 mm×0.25 μm）, carrier gas was helium for chromatography R, detector was 300 ℃, detection was flame ionization,injection port was 220 ℃. Results： The linear ranges of Memantine Hydrochloride and the related substance were 5~120 μg/m L. The average recovery of Memantine Hydrochloride was 97.5 %、95.3 %、96.7 %、94.2 % and 98.4 %. Conclusion： The method to determine the assay of Memantine Hydrochloride is simple, sensitive and accurate.
出处
《广东化工》
CAS
2015年第20期134-134,131,共2页
Guangdong Chemical Industry
关键词
GC法
FID
有关物质
测定
Memantine Hydrochloride
GC method
the related substance
determination
